5f3a: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5f3a is ~~ON HOLD until Dec 02 2017~~

==Crystal structure of the bromodomain of human ATAD2 in complex with Compound A14==

~~Authors~~: ~~Dong~~, J., ~~Caflisch~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5f3a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F3A OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F3A FirstGlance].

~~Description~~: ~~Crystal structure~~ of the ~~bromodomain~~ of ~~human ATAD2~~ in ~~complex with Compound A14~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=5U9:~{N}-(4-ETHANOYL-1,3-THIAZOL-2-YL)AZETIDIN-1-IUM-3-CARBOXAMIDE'>5U9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f3a OCA], [http://pdbe.org/5f3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f3a RCSB], [http://www.ebi.ac.uk/pdbsum/5f3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f3a ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Adenosinetriphosphatase]]

[[Category: Caflisch, A]]

[[Category: Dong, J]]

[[Category: ~~Caflisch, A~~]]

[[Category: Hydrolase inhibitor complex]]

[[Category: Transferase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5f3a is ON HOLD  until Dec 02 2017
+==Crystal structure of the bromodomain of human ATAD2 in complex with Compound A14==
+<StructureSection load='5f3a' size='340' side='right' caption='[[5f3a]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-Authors: Dong, J., Caflisch, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5f3a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F3A FirstGlance]. <br>
-Description: Crystal structure of the bromodomain of human ATAD2 in complex with Compound A14
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5U9:~{N}-(4-ETHANOYL-1,3-THIAZOL-2-YL)AZETIDIN-1-IUM-3-CARBOXAMIDE'>5U9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f3a OCA], [http://pdbe.org/5f3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f3a RCSB], [http://www.ebi.ac.uk/pdbsum/5f3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f3a ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Adenosinetriphosphatase]]
+[[Category: Caflisch, A]]
 [[Category: Dong, J]]
-[[Category: Caflisch, A]]
+[[Category: Hydrolase inhibitor complex]]
+[[Category: Transferase]]