5f73: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5f73 is ~~ON HOLD until Dec 14 2017~~

==Crystal structure of Mutant S12T of Adenosine/Methylthioadenosine Phosphorylase in APO form==

~~Authors~~: ~~Torini~~, J.R.S., ~~Brandao~~-~~Neto~~, J., ~~DeMarco~~, R., ~~Pereira, H~~.M.

== Structural highlights ==

<table><tr><td colspan='2'>[[5f73]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F73 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F73 FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~Mutant S12T~~ of ~~Adenosine~~/~~Methylthioadenosine Phosphorylase in APO form~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f73 OCA], [http://pdbe.org/5f73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f73 RCSB], [http://www.ebi.ac.uk/pdbsum/5f73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f73 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/I0B503_SCHMA I0B503_SCHMA]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates (By similarity).[HAMAP-Rule:MF_03155]

__TOC__

</StructureSection>

[[Category: S-methyl-5'-thioadenosine phosphorylase]]

[[Category: Brandao-Neto, J]]

[[Category: ~~Pereira~~, ~~H.M~~]]

[[Category: DeMarco, R]]

[[Category: ~~Demarco~~, R]]

[[Category: Pereira, H M]]

[[Category: Torini, J.R.S]]

[[Category: Torini, J R.S]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5f73 is ON HOLD  until Dec 14 2017
+==Crystal structure of Mutant S12T of Adenosine/Methylthioadenosine Phosphorylase in APO form==
+<StructureSection load='5f73' size='340' side='right' caption='[[5f73]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
-Authors: Torini, J.R.S., Brandao-Neto, J., DeMarco, R., Pereira, H.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5f73]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F73 FirstGlance]. <br>
-Description: Crystal structure of Mutant S12T of Adenosine/Methylthioadenosine Phosphorylase in APO form
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l6i|4l6i]], [[4l5a|4l5a]], [[4l5c|4l5c]], [[4l5y|4l5y]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f73 OCA], [http://pdbe.org/5f73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f73 RCSB], [http://www.ebi.ac.uk/pdbsum/5f73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f73 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/I0B503_SCHMA I0B503_SCHMA]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates (By similarity).[HAMAP-Rule:MF_03155]
+__TOC__
+</StructureSection>
+[[Category: S-methyl-5'-thioadenosine phosphorylase]]
 [[Category: Brandao-Neto, J]]
-[[Category: Pereira, H.M]]
+[[Category: DeMarco, R]]
-[[Category: Demarco, R]]
+[[Category: Pereira, H M]]
-[[Category: Torini, J.R.S]]
+[[Category: Torini, J R.S]]
+[[Category: Transferase]]