ERGIC-53: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''ER-Golgi Intermediate Compartment-53 (ERGIC-53)''' is a transmembr... |
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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== Function == | == Function == | ||
'''ER-Golgi Intermediate Compartment-53 (ERGIC-53)''' is a transmembrane protein which acts as a receptor of glycoproteins and transports them from the ER to ER-Golgi Intermediate Compartment and Golgi<ref>PMID:19609866</ref>. | '''ER-Golgi Intermediate Compartment-53 (ERGIC-53)''' is a transmembrane protein which acts as a receptor of glycoproteins and transports them from the ER to ER-Golgi Intermediate Compartment and Golgi<ref>PMID:19609866</ref>. | ||
== Relevance == | == Relevance == | ||
Some ER storage diseases have relationship with | Some ER storage diseases have relationship with ERGIC-53. ERGIC-53 is required for the propagation of arenavirus, coronavirus and filovirus<ref>PMID:24237698</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. | ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. The mannose-binding pocket of ERGIC-53 contains a Ca+2 ion as well<ref>PMID:23709226</ref>. | ||
</StructureSection> | |||
==3D structures of ERGIC-53== | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[4ygb]], [[4ygc]], [[4ygd]], [[4yge]], [[3wht]], [[3lcp]], [[3a4u]] – hERGIC-53 CRD domain + MCFD2 + Ca - human<br /> | |||
[[3whu]], [[3wnx]] – hERGIC-53 CRD domain + MCFD2 + Ca + mannose<br /> | |||
[[4gkx]] – hERGIC-53 CRD domain + Ca <br /> | |||
[[4gky]] – hERGIC-53 CRD domain + Ca + mannose<br /> | |||
[[1r1z]] – rERGIC-53 CRD domain + Ca - rat<br /> | |||
[[1gv9]] – rERGIC-53 CRD domain <br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
