5fa3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5fa3 is ~~ON HOLD until Paper Publication~~

==Structure of HLA-A2:01 with peptide G9V==

~~Authors~~: ~~Zajonc~~, D.M., ~~Remesh~~, S.G.

== Structural highlights ==

<table><tr><td colspan='2'>[[5fa3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FA3 FirstGlance]. <br>

~~Description~~: ~~Structure~~ of ~~HLA~~-A2:~~01 with peptide G9V~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fa3 OCA], [http://pdbe.org/5fa3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fa3 RCSB], [http://www.ebi.ac.uk/pdbsum/5fa3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fa3 ProSAT]</span></td></tr>

[[Category: Remesh, S.G]]

</table>

[[Category: Zajonc, D.M]]

== Disease ==

[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>

== Function ==

[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

== References ==

__TOC__

</StructureSection>

[[Category: Remesh, S G]]

[[Category: Zajonc, D M]]

[[Category: Immune system]]

[[Category: Mhc]]

[[Category: Peptide complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5fa3 is ON HOLD  until Paper Publication
+==Structure of HLA-A2:01 with peptide G9V==
+<StructureSection load='5fa3' size='340' side='right' caption='[[5fa3]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
-Authors: Zajonc, D.M., Remesh, S.G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fa3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FA3 FirstGlance]. <br>
-Description: Structure of HLA-A2:01 with peptide G9V
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fa3 OCA], [http://pdbe.org/5fa3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fa3 RCSB], [http://www.ebi.ac.uk/pdbsum/5fa3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fa3 ProSAT]</span></td></tr>
-[[Category: Remesh, S.G]]
+</table>
-[[Category: Zajonc, D.M]]
+== Disease ==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Remesh, S G]]
+[[Category: Zajonc, D M]]
+[[Category: Immune system]]
+[[Category: Mhc]]
+[[Category: Peptide complex]]