5ium: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ium is ~~ON HOLD until Paper Publication~~

==Crystal structure of phosphorylated DesKC==

~~Authors~~: ~~Trajtenberg~~, F., ~~Buschiazzo~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ium]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUM OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IUM FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~phosphorylated DesKC~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=NEP:N1-PHOSPHONOHISTIDINE'>NEP</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ium FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ium OCA], [http://pdbe.org/5ium PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ium RCSB], [http://www.ebi.ac.uk/pdbsum/5ium PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ium ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DESK_BACSU DESK_BACSU]] Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates DesR by phosphorylation.<ref>PMID:11285232</ref> <ref>PMID:11717295</ref> <ref>PMID:12207704</ref> <ref>PMID:14734164</ref> <ref>PMID:15090506</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Histidine kinase]]

[[Category: Buschiazzo, A]]

[[Category: Trajtenberg, F]]

[[Category: Cell membrane]]

[[Category: Four-helix bundle]]

[[Category: Ghl atpase domain]]

[[Category: Kinase]]

[[Category: Membrane]]

[[Category: Phosphoprotein]]

[[Category: Transferase]]

[[Category: Transmembrane]]

[[Category: Two-component regulatory system]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ium is ON HOLD  until Paper Publication
+==Crystal structure of phosphorylated DesKC==
+<StructureSection load='5ium' size='340' side='right' caption='[[5ium]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
-Authors: Trajtenberg, F., Buschiazzo, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ium]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IUM FirstGlance]. <br>
-Description: Crystal structure of phosphorylated DesKC
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NEP:N1-PHOSPHONOHISTIDINE'>NEP</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gig|3gig]], [[5iuj|5iuj]], [[5iuk|5iuk]], [[5iul|5iul]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ium FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ium OCA], [http://pdbe.org/5ium PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ium RCSB], [http://www.ebi.ac.uk/pdbsum/5ium PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ium ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DESK_BACSU DESK_BACSU]] Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates DesR by phosphorylation.<ref>PMID:11285232</ref> <ref>PMID:11717295</ref> <ref>PMID:12207704</ref> <ref>PMID:14734164</ref> <ref>PMID:15090506</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Histidine kinase]]
 [[Category: Buschiazzo, A]]
 [[Category: Trajtenberg, F]]
+[[Category: Cell membrane]]
+[[Category: Four-helix bundle]]
+[[Category: Ghl atpase domain]]
+[[Category: Kinase]]
+[[Category: Membrane]]
+[[Category: Phosphoprotein]]
+[[Category: Transferase]]
+[[Category: Transmembrane]]
+[[Category: Two-component regulatory system]]