5l6y: Difference between revisions
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==il13 in complex with tralokinumab== | |||
<StructureSection load='5l6y' size='340' side='right' caption='[[5l6y]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5l6y]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L6Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L6Y FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l6y OCA], [http://pdbe.org/5l6y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l6y RCSB], [http://www.ebi.ac.uk/pdbsum/5l6y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l6y ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Breed, J]] | |||
[[Category: Il13]] | |||
[[Category: Il13 antibody tralokinumab asthma]] | |||
[[Category: Immune system]] | |||
Revision as of 21:43, 22 December 2016
il13 in complex with tralokinumab
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