Hydroxysteroid dehydrogenase: Difference between revisions
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<StructureSection load='1lwi' size=' | <StructureSection load='1lwi' size='350' side='right' scene='49/491805/Cv/1' caption='Rat 3-α hydroxysteroid dehydrogenase dimer complex with cofactor NADP [[1lwi]]'> | ||
== Function == | == Function == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*3-α HSD | *3-α HSD or AKR1C2 | ||
'''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]] | '''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]] | ||
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**[[1afs]] - rHSD + hydroxysteroid + NADP<BR /> | **[[1afs]] - rHSD + hydroxysteroid + NADP<BR /> | ||
**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4 | **[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP - human<br /> | ||
*3-α HSD type 3 | *3-α HSD type 3 | ||
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**[[4l1w]] - hHSD + progesterone + NADP<br /> | **[[4l1w]] - hHSD + progesterone + NADP<br /> | ||
**[[4l1x]] - hHSD (mutant) + progesterone + NADP<br /> | **[[4l1x]] - hHSD (mutant) + progesterone + NADP<br /> | ||
**[[4xo6]], [[4xo7]] – hHSD + NADP + epiandrosterone derivative<br /> | |||
*7-α HSD | *7-α HSD | ||
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**[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD | **[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD | ||
*20-α HSD | *20-α HSD or AKR1C1 | ||
**[[1q5m]] - raHSD + NADP – rabbit | **[[1q5m]] - raHSD + NADP – rabbit | ||
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**[[1mrq]] – hHSD + hydroxysteroid + NADP<BR /> | **[[1mrq]] – hHSD + hydroxysteroid + NADP<BR /> | ||
**[[4yvp]] – hHSD + NADP + sulfonylurea derivative<br /> | |||
**[[3c3u]], [[3nty]] - hHSD + inhibitor + NADP<BR /> | **[[3c3u]], [[3nty]] - hHSD + inhibitor + NADP<BR /> | ||
**[[3gug]] - hHSD (mutant) + inhibitor + NADP<BR /> | **[[3gug]] - hHSD (mutant) + inhibitor + NADP<BR /> | ||
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**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]] - hHSD 1 (mutant) + inhibitor + NADP<BR /> | **[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]] - hHSD 1 (mutant) + inhibitor + NADP<BR /> | ||
*17-α HSD | *17-α HSD or AKR1C21 | ||
**[[3fjn]] - mHSD (mutant) | **[[2he8]] – mHSD - mouse <br /> | ||
**[[2p5n]] - mHSD + NADP <br /> | **[[3fjn]] - mHSD (mutant) <br /> | ||
**[[2p5n]], [[2he5]], [[2hej]] - mHSD + NADP <br /> | |||
**[[2ipf]] - mHSD + hydroxysteroid + NADP <br /> | **[[2ipf]] - mHSD + hydroxysteroid + NADP <br /> | ||
**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br /> | **[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br /> | ||
