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'''Unreleased structure'''


The entry 5kzn is ON HOLD  until Paper Publication
==Metabotropic Glutamate Receptor==
 
<StructureSection load='5kzn' size='340' side='right' caption='[[5kzn]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors: Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5kzn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KZN FirstGlance]. <br>
Description: Metabotropic Glutamate Receptor
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kzq|5kzq]]</td></tr>
[[Category: Groshong, C]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kzn OCA], [http://pdbe.org/5kzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kzn RCSB], [http://www.ebi.ac.uk/pdbsum/5kzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kzn ProSAT]</span></td></tr>
[[Category: Jaramillo, C]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Antonysamy, S]]
[[Category: Atwell, S]]
[[Category: Barberis, M]]
[[Category: Barberis, M]]
[[Category: Bedwell, D]]
[[Category: Blanco, M J]]
[[Category: Bradley, C]]
[[Category: Britton, T]]
[[Category: Britton, T]]
[[Category: Mayhugh, D]]
[[Category: Wasserman, S.R]]
[[Category: Zhang, A]]
[[Category: Bradley, C]]
[[Category: Blanco, M.-J]]
[[Category: Bedwell, D]]
[[Category: Quimby, S.J]]
[[Category: Bures, M]]
[[Category: Bures, M]]
[[Category: Li, R]]
[[Category: Witkin, J.M]]
[[Category: Wang, J]]
[[Category: Ornstein, P]]
[[Category: Macewan, I]]
[[Category: Smith, S.C]]
[[Category: Seidel, W]]
[[Category: Chappell, M.D]]
[[Category: Carpintero, M]]
[[Category: Carpintero, M]]
[[Category: Erickson, J.A]]
[[Category: Catlow, J]]
[[Category: Catlow, J]]
[[Category: Wafford, K.A]]
[[Category: Chappell, M D]]
[[Category: Vetman, T]]
[[Category: Monn, J.A]]
[[Category: Soriano, J.F]]
[[Category: Tromiczak, E.G]]
[[Category: Matt, J]]
[[Category: Mitch, C.H]]
[[Category: Swanson, S]]
[[Category: Atwell, S]]
[[Category: Condon, B]]
[[Category: Condon, B]]
[[Category: Conners, K]]
[[Category: Conners, K]]
[[Category: Wang, X.-S]]
[[Category: Diego, J E.de]]
[[Category: Dressman, B A]]
[[Category: Erickson, J A]]
[[Category: Fivush, A M]]
[[Category: Garcia-Cerrada, S]]
[[Category: Groshong, C]]
[[Category: Heinz, B A]]
[[Category: Jaramillo, C]]
[[Category: Koss, J W]]
[[Category: Li, R]]
[[Category: Li, X]]
[[Category: MacEwan, I]]
[[Category: Matt, J]]
[[Category: Mayhugh, D]]
[[Category: Mitch, C H]]
[[Category: Monn, J A]]
[[Category: Ornstein, P]]
[[Category: Overshiner, C]]
[[Category: Overshiner, C]]
[[Category: Li, X]]
[[Category: Quimby, S J]]
[[Category: Koss, J.W]]
[[Category: Schkeryantz, J M]]
[[Category: Dressman, B.A]]
[[Category: Seidel, W]]
[[Category: De Diego, J.E]]
[[Category: Smith, S C]]
[[Category: Tripp, A.E]]
[[Category: Soriano, J F]]
[[Category: Garcia-Cerrada, S]]
[[Category: Swanson, S]]
[[Category: Schkeryantz, J.M]]
[[Category: Tripp, A E]]
[[Category: Heinz, B.A]]
[[Category: Tromiczak, E G]]
[[Category: Fivush, A.M]]
[[Category: Vetman, T]]
[[Category: Antonysamy, S]]
[[Category: Wafford, K A]]
[[Category: Wang, J]]
[[Category: Wang, X S]]
[[Category: Wasserman, S R]]
[[Category: Witkin, J M]]
[[Category: Zhang, A]]
[[Category: Antagonist]]
[[Category: Antidepressent]]
[[Category: Mglur2]]
[[Category: Signaling protein]]

Revision as of 16:25, 2 January 2017

Metabotropic Glutamate Receptor

5kzn, resolution 2.80Å

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