5tkd: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 5tkd is ON HOLD until Paper Publication~~

==CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE==

~~Authors: Muckelbauer, J.K.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5tkd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKD OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TKD FirstGlance].

~~Description:~~ CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8-(METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=7GL:6-[(3,5-DIMETHYLPHENYL)AMINO]-8-(METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXAMIDE'>7GL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </td></tr>

[[Category: Muckelbauer, J.K]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tkd OCA], [http://pdbe.org/5tkd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tkd RCSB], [http://www.ebi.ac.uk/pdbsum/5tkd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tkd ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.

== Function ==

[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Non-specific protein-tyrosine kinase]]

[[Category: Muckelbauer, J K]]

[[Category: Kinase]]

[[Category: Pseudokinase]]

[[Category: Transferase]]

[[Category: Tyk2]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5tkd is ON HOLD  until Paper Publication
+==CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE==
+<StructureSection load='5tkd' size='340' side='right' caption='[[5tkd]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
-Authors: Muckelbauer, J.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5tkd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TKD FirstGlance]. <br>
-Description: CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8-(METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7GL:6-[(3,5-DIMETHYLPHENYL)AMINO]-8-(METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXAMIDE'>7GL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-[[Category: Muckelbauer, J.K]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tkd OCA], [http://pdbe.org/5tkd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tkd RCSB], [http://www.ebi.ac.uk/pdbsum/5tkd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tkd ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
+== Function ==
+[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Non-specific protein-tyrosine kinase]]
+[[Category: Muckelbauer, J K]]
+[[Category: Kinase]]
+[[Category: Pseudokinase]]
+[[Category: Transferase]]
+[[Category: Tyk2]]