OBrochtasSandbox: Difference between revisions
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==O'Brochta's Sandbox == 0 | ==O'Brochta's Sandbox == 0 | ||
<StructureSection load='Model.itasser.relax.pdb' size='400' side='right' caption='Anopheles arabiensis InR kinase domain model' scene | <StructureSection load='Model.itasser.relax.pdb' size='400' side='right' caption='Anopheles arabiensis InR kinase domain model' scene='Insert optional scene name here' /> | ||
The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project' | The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project' | ||
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And as a <scene name='75/750300/Geneticmutationsspacefilled/1'>spacefilled model</scene> | And as a <scene name='75/750300/Geneticmutationsspacefilled/1'>spacefilled model</scene> | ||
<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | |||
Revision as of 21:20, 15 January 2017
==O'Brochta's Sandbox == 0
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The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project'
This shows the basic structure of the kinase domain with an N and C lobe. The ATP will sit between them just below Beta 1
This shows the ATP binding site (purple) and the catalytic loop (green). Here it is as a spacefilled model.
These are three ts mutations found in other RTKs.
G1000S (magenta), A1133G (orange), T1221I (teal)
And as a spacefilled model
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