OBrochtasSandbox: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 15: | Line 15: | ||
And as a <scene name='75/750300/Geneticmutationsspacefilled/1'>spacefilled model</scene> | And as a <scene name='75/750300/Geneticmutationsspacefilled/1'>spacefilled model</scene> | ||
< | |||
This <scene name='75/750300/T1221_spacefilled/1'>threonine</scene> when mutated to isoleucine resulted in ts lethal mutations in the sevenless and EGFR-like genes in D. melanogster | |||
Revision as of 18:06, 16 January 2017
==O'Brochta's Sandbox == 0
|
The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project'
This shows the basic structure of the kinase domain with an N and C lobe. The ATP will sit between them just below Beta 1
This shows the ATP binding site (purple) and the catalytic loop (green). Here it is as a spacefilled model.
These are three ts mutations found in other RTKs.
G1000S (magenta), A1133G (orange), T1221I (teal)
And as a spacefilled model
This threonine when mutated to isoleucine resulted in ts lethal mutations in the sevenless and EGFR-like genes in D. melanogster
