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Anopheles arabiensis Insulin Receptor like Protein

spinqualitylabelsall models Anopheles arabiensis InR kinase domain model Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project'

This shows the basic structure of the kinase domain with an N and C lobe. The ATP will sit between them just below Beta 1

This shows the ATP binding site (purple) and the catalytic loop (green). Here it is as a spacefilled model.

These are three ts mutations found in other RTKs.

G1000S (magenta), A1133G (orange), T1221I (teal)

And as a spacefilled model

This threonine when mutated to isoleucine resulted in ts lethal mutations in the sevenless and EGFR-like genes in D. melanogster

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David O'Brochta