Methotrexate: Difference between revisions

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The nature of this binding has a 1000 fold increase in affinity relative to the natural folate affinity of DHFR, producing a practically irreversible inhibition of DHFR activity. Methotrexate is a competitive inhibitor that can bind to and inhibit the <scene name='42/420816/Cv/6'>active site of human DHFR</scene> ([[1u72]]). The ~~active site is buried within the enzyme as is depicted by the~~ <scene name='~~Sandbox_58~~/~~Solvent_accessable_surface~~/1'>~~solvent accessable surface~~</scene> ~~shown in orange at the entrance to the active site~~. The

The nature of this binding has a 1000 fold increase in affinity relative to the natural folate affinity of DHFR, producing a practically irreversible inhibition of DHFR activity. Methotrexate is a competitive inhibitor that can bind to and inhibit the <scene name='42/420816/Cv/6'>active site of human DHFR</scene> ([[1u72]]). The <scene name='42/420816/Cv/7'>active site is buried within the enzyme</scene>. The <scene name='Sandbox_58/Relative_temperature/1'>relative temperature</scene> are color depictions of each atom in regards to mobility or position uncertainty relative to the molecule, with increasing mobility as the color scheme goes from blue to red.

<scene name='Sandbox_58/Relative_temperature/1'>relative temperature</scene> are color depictions of each atom in regards to mobility or position uncertainty relative to the molecule, with increasing mobility as the color scheme goes from blue to red.

Methotrexate: Difference between revisions

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Revision as of 13:03, 17 January 2017 view source Alexander Berchansky (talk \| contribs) 29,726 edits No edit summary ← Older edit		Revision as of 13:12, 17 January 2017 view source Alexander Berchansky (talk \| contribs) 29,726 edits No edit summary Newer edit →
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	The nature of this binding has a 1000 fold increase in affinity relative to the natural folate affinity of DHFR, producing a practically irreversible inhibition of DHFR activity. Methotrexate is a competitive inhibitor that can bind to and inhibit the <scene name='42/420816/Cv/6'>active site of human DHFR</scene> ([[1u72]]). The ~~active site is buried within the enzyme as is depicted by the~~ <scene name='~~Sandbox_58~~/~~Solvent_accessable_surface~~/1'>~~solvent accessable surface~~</scene> ~~shown in orange at the entrance to the active site~~. The		The nature of this binding has a 1000 fold increase in affinity relative to the natural folate affinity of DHFR, producing a practically irreversible inhibition of DHFR activity. Methotrexate is a competitive inhibitor that can bind to and inhibit the <scene name='42/420816/Cv/6'>active site of human DHFR</scene> ([[1u72]]). The <scene name='42/420816/Cv/7'>active site is buried within the enzyme</scene>. The <scene name='Sandbox_58/Relative_temperature/1'>relative temperature</scene> are color depictions of each atom in regards to mobility or position uncertainty relative to the molecule, with increasing mobility as the color scheme goes from blue to red.
	<scene name='Sandbox_58/Relative_temperature/1'>relative temperature</scene> are color depictions of each atom in regards to mobility or position uncertainty relative to the molecule, with increasing mobility as the color scheme goes from blue to red.