5g60: Difference between revisions
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==S.pneumoniae ABC-transporter substrate binding protein FusA in complex with nystose== | |||
<StructureSection load='5g60' size='340' side='right' caption='[[5g60]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5g60]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G60 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NYT:BETA-D-FRUCTOFURANOSYL-(2- 1)-BETA-D-FRUCTOFURANOSYL-(2- 1)-BETA-D-FRUCTOFURANOSYL+ALPHA-D-GLUCOPYRANOSIDE'>NYT</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g5y|5g5y]], [[5g5z|5g5z]], [[5g61|5g61]], [[5g62|5g62]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g60 OCA], [http://pdbe.org/5g60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g60 RCSB], [http://www.ebi.ac.uk/pdbsum/5g60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g60 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Streptococcus pneumoniae is dependent on carbohydrate uptake for colonization and pathogenesis, and dedicates over a third of its transport systems to their uptake. The ability of the pneumococcus to utilize fructooligosaccharides (FOSs) is attributed to the presence of one of two types of FOS ATP-binding cassette (ABC) transporters. Strains encoding SfuABC are only able to utilize short-chain FOSs, while strains encoding FusABC can utilize both short- and long-chain FOSs. The crystal structures of the substrate-binding protein FusA in its open and closed conformations bound to FOSs, and solution scattering data of SfuA, delineate the structural basis for import of short- and long-chain FOSs. The structure of FusA identifies an EF hand-like calcium-binding motif. This is shown to be essential for translocation of FOSs in FusABC and forms the basis for the definition of a new class of substrate-binding proteins that regulate substrate translocation by calcium. | |||
Structural Basis for Regulation and Specificity of Fructooligosaccharide Import in Streptococcus pneumoniae.,Culurgioni S, Harris G, Singh AK, King SJ, Walsh MA Structure. 2017 Jan 3;25(1):79-93. doi: 10.1016/j.str.2016.11.008. Epub 2016 Dec , 8. PMID:27939783<ref>PMID:27939783</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5g60" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Culurgioni, S]] | [[Category: Culurgioni, S]] | ||
[[Category: Harris, G]] | [[Category: Harris, G]] | ||
[[Category: Singh, A | [[Category: King, S J]] | ||
[[Category: Singh, A K]] | |||
[[Category: Walsh, M A]] | |||
[[Category: Abc-transporter]] | |||
[[Category: Carbohydrate]] | |||
[[Category: Fructo-nystose]] | |||
[[Category: Fructooligosaccharide]] | |||
[[Category: Fusa]] | |||
[[Category: Kestose]] | |||
[[Category: Nystose]] | |||
[[Category: Pneumoniae]] | |||
[[Category: Substrate-binding-protein]] | |||
[[Category: Sugar]] | |||
[[Category: Transport]] | |||
[[Category: Transport protein]] | |||
[[Category: Transporter]] | |||
