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| <StructureSection load='5c4m' size='340' side='right' caption='Caption for this structure' scene=''> | | <StructureSection load='5c4m' size='340' side='right' caption='Caption for this structure' scene=''> |
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| == Disease == | | == Disease == |
| | Mutations in RhoA were identified in diffuse gastric cancer<ref>PMID:25026207</ref>. |
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| == Relevance == | | == Relevance == |
| | RhoA is thought to be important in mediating vasoconstriction in the penis<ref>PMID:16411892</ref>. |
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| == Structural highlights == | | == Structural highlights == |
Revision as of 07:55, 8 February 2017
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Function
Rho GTPase of higher vertebrates include RhoA, RhoB and RhoC. These 3 proteins share 85% sequence identity. RhoA is the more extensively studied among these three. RhoA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. A number of proteins have been identified as targets of RhoA[1].
Disease
Mutations in RhoA were identified in diffuse gastric cancer[2].
Relevance
RhoA is thought to be important in mediating vasoconstriction in the penis[3].
Structural highlights
- ↑ Sepp KJ, Auld VJ. RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia. Development. 2003 May;130(9):1825-35. PMID:12642488
- ↑ Zhou J, Hayakawa Y, Wang TC, Bass AJ. RhoA mutations identified in diffuse gastric cancer. Cancer Cell. 2014 Jul 14;26(1):9-11. doi: 10.1016/j.ccr.2014.06.022. PMID:25026207 doi:https://dx.doi.org/10.1016/j.ccr.2014.06.022
- ↑ Jin L, Burnett AL. RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights. Clin Sci (Lond). 2006 Feb;110(2):153-65. PMID:16411892 doi:https://dx.doi.org/10.1042/CS20050255
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3D structures of Rho GTPase
Updated on 08-February-2017
{"openlevels":0}
- RhoA
- RhoA complex with guanine nucleotide exchange factor
- 4xh9 – hRhoA (mutant) + guanine nucleotide exchange factor NET1
- 3t06, 1xcg – hRhoA (mutant) + guanine nucleotide exchange factor 11
- 1lb1 – hRhoA (mutant) + guanine nucleotide exchange factor Dbs
- 3kz1 – hRhoA + guanine nucleotide exchange factor 11 + GSP
- 1x86 – hRhoA + guanine nucleotide exchange factor 12
- RhoA complex with Rho GTPase-activating protein
- 5irc – hRhoA + Rho GTPase-activating protein 20 + GDP
- 1ow3 – hRhoA + Rho GTPase-activating protein 1 + GDP
- 3msx – hRhoA (mutant) + Rho GTPase-activating protein 35 + GDP
- RhoA complex with ADP-ribosyltransferase
- 4xsg – hRhoA (mutant) + ADP-ribosyltransferase + GTP
- 4xsh – hRhoA (mutant) + ADP-ribosyltransferase + GSP + NADH
- 5bwm – hRhoA (mutant) + ADP-ribosyltransferase + GDP + NADH
- RhoA other complexes
- 5fr2, 5fr1, 1cc0 – hRhoA + Rho GDP-dissociation inhibitor 1 + GDP
- 5hpy – hRhoA (mutant) + unconventional myosin-IXB + GDP
- 4xoi – hRhoA (mutant) + actin-binding protein anillin + GTP
- 4f38 – mRhoA + Rho GDP-dissociation inhibitor 1 + GPPNP
- 4d0n – hRhoA + A-kinase anchor protein 13 + GDP
- 3lw8, 3lwn, 3lxr – hRhoA + IpgB2 + GDP
- 1s1c – hRhoA + ROCKI + GNP
- 1cxz – hRhoA + Pkn/Prk1 + GSP
- 1tx4 – hRhoA + RhoGap + GDP
- 2rgn – hRhoA + guanine nucleotide-binding protein alpha-Q + RhoA/Rac/CDC42 exchange factor + GDP
- 5c2k – hRhoA/Rac GTPase-activating protein 1 + GDP
- 5jcp – hRhoA/ARAP3 + GDP
- RhoB
- RhoC
- 2gcn – hRhoC + GDP
- 2gco – hRhoC + GPPNP
- 2gcp – hRhoC + GSP
- 2gcn – hRhoC (mutant) + diaphanous protein homolog 1 + GMPPNP
References
