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<StructureSection load='5jbh' size='340' side='right' caption='[[5jbh]], [[Resolution|resolution]] 5.34&Aring;' scene=''>
<StructureSection load='5jbh' size='340' side='right' caption='[[5jbh]], [[Resolution|resolution]] 5.34&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5jbh]] is a 35 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Pyrococcus Pyrococcus], [http://en.wikipedia.org/wiki/Pyrococcus_abyssi_(strain_ge5_/_orsay) Pyrococcus abyssi (strain ge5 / orsay)], [http://en.wikipedia.org/wiki/Pyrococcus_abyssi_ge5 Pyrococcus abyssi ge5], [http://en.wikipedia.org/wiki/Pyrococcus_furiosus_(strain_atcc_43587_/_dsm_3638_/_jcm_8422_/_vc1) Pyrococcus furiosus (strain atcc 43587 / dsm 3638 / jcm 8422 / vc1)], [http://en.wikipedia.org/wiki/Pyrococcus_furiosus_com1 Pyrococcus furiosus com1] and [http://en.wikipedia.org/wiki/Pyrococcus_furiosus_dsm_3638 Pyrococcus furiosus dsm 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JBH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JBH FirstGlance]. <br>
<table><tr><td colspan='2'>[[5jbh]] is a 35 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Pyrococcus_abyssi_ge5 Pyrococcus abyssi ge5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JBH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JBH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jbh OCA], [http://pdbe.org/5jbh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jbh RCSB], [http://www.ebi.ac.uk/pdbsum/5jbh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jbh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jbh OCA], [http://pdbe.org/5jbh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jbh RCSB], [http://www.ebi.ac.uk/pdbsum/5jbh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jbh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/IF1A_PYRAB IF1A_PYRAB]] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity). [[http://www.uniprot.org/uniprot/RS8_PYRFU RS8_PYRFU]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit. [[http://www.uniprot.org/uniprot/RS3_PYRFU RS3_PYRFU]] Binds the lower part of the 30S subunit head. [[http://www.uniprot.org/uniprot/RS17_PYRFU RS17_PYRFU]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS11_PYRAB RS11_PYRAB]] Located on the platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/RS5_PYRFU RS5_PYRFU]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/IF2B_SULSO IF2B_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity). [[http://www.uniprot.org/uniprot/RS4_PYRAB RS4_PYRAB]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.  With S5 and S12 plays an important role in translational accuracy. [[http://www.uniprot.org/uniprot/RS14Z_PYRFU RS14Z_PYRFU]] Binds 16S rRNA, required for the assembly of 30S particles. [[http://www.uniprot.org/uniprot/RL7A_PYRFU RL7A_PYRFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity). [[http://www.uniprot.org/uniprot/IF2A_SULSO IF2A_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity). [[http://www.uniprot.org/uniprot/I6U894_9EURY I6U894_9EURY]] May be involved in maturation of the 30S ribosomal subunit.[HAMAP-Rule:MF_01474] [[http://www.uniprot.org/uniprot/RS7_PYRFU RS7_PYRFU]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center. [[http://www.uniprot.org/uniprot/RS12_PYRAB RS12_PYRAB]] With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. [[http://www.uniprot.org/uniprot/RS19_PYRFU RS19_PYRFU]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS10_PYRFU RS10_PYRFU]] Involved in the binding of tRNA to the ribosomes. [[http://www.uniprot.org/uniprot/IF2G_SULSO IF2G_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity). [[http://www.uniprot.org/uniprot/RS13_PYRFU RS13_PYRFU]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pyrococcus]]
[[Category: Pyrococcus abyssi ge5]]
[[Category: Pyrococcus abyssi ge5]]
[[Category: Pyrococcus furiosus com1]]
[[Category: Pyrococcus furiosus dsm 3638]]
[[Category: COUREUX, P D]]
[[Category: COUREUX, P D]]
[[Category: MECHULAM, Y]]
[[Category: MECHULAM, Y]]
[[Category: SCHMITT, E]]
[[Category: SCHMITT, E]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 07:44, 9 March 2017

Cryo-EM structure of a full archaeal ribosomal translation initiation complex in the P-IN conformation

5jbh, resolution 5.34Å

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