1t7s: Difference between revisions
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
|GENE= Bag-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans]) | |GENE= Bag-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans]) | ||
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00264 BAG], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK07577 PRK07577]</span> | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00264 BAG], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK07577 PRK07577]</span> | ||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t7s OCA], [http://www.ebi.ac.uk/pdbsum/1t7s PDBsum | |RELATEDENTRY=[[1hx1|1HX1]], [[1i6z|1I6Z]] | ||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t7s OCA], [http://www.ebi.ac.uk/pdbsum/1t7s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t7s RCSB]</span> | |||
}} | }} | ||
| Line 40: | Line 41: | ||
[[Category: structural genomic]] | [[Category: structural genomic]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:52:34 2008'' | ||
Revision as of 20:52, 30 March 2008
| |||||||||||||
| 1t7s, resolution 2.80Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | MSE | ||||||||||||
| Gene: | Bag-1 (Caenorhabditis elegans) | ||||||||||||
| Domains: | BAG, PRK07577 | ||||||||||||
| Related: | 1HX1, 1I6Z
| ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein
Overview
Binding of the BAG domain to the eukaryotic chaperone heat-shock protein (Hsp70) promotes ATP-dependent release of the protein substrate from Hsp70. Although the murine and human BAG domains have been shown to form an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain is formed by two antiparallel helices, while the third helix is extended away and stabilized by crystal-packing interactions. A small beta-sheet between helices 2 and 3 interferes with formation of the intramolecular three-helix bundle. However, intermolecular three-helix bundles are observed throughout the crystal packing and suggest that stable functional dimers and tetramers can be formed in solution. The structure may represent a new folding type of the BAG domain.
About this Structure
1T7S is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.
Reference
Structural genomics of Caenorhabditis elegans: structure of the BAG domain., Symersky J, Zhang Y, Schormann N, Li S, Bunzel R, Pruett P, Luan CH, Luo M, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1606-10. Epub 2004, Aug 26. PMID:15333932
Page seeded by OCA on Sun Mar 30 23:52:34 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Caenorhabditis elegans
- Single protein
- Bunzel, R.
- Li, S.
- Luan, C H.
- Luo, M.
- Pruett, P.
- SECSG, Southeast Collaboratory for Structural Genomics.
- Schormann, N.
- Symersky, J.
- Zhang, Y.
- Bag-1 cochaperone
- Protein structure initiative
- Psi
- Secsg
- Southeast collaboratory for structural genomic
- Structural genomic
