5f61: Difference between revisions
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==Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-1== | |||
<StructureSection load='5f61' size='340' side='right' caption='[[5f61]], [[Resolution|resolution]] 1.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5f61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F61 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5W0:~{N}-[3-[[2-[[3-FLUORANYL-4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO]-5-METHYL-PYRIMIDIN-4-YL]AMINO]PHENYL]-2-METHYL-PROPANE-2-SULFONAMIDE'>5W0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f5z|5f5z]], [[5f60|5f60]], [[5f62|5f62]], [[5f63|5f63]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f61 OCA], [http://pdbe.org/5f61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f61 RCSB], [http://www.ebi.ac.uk/pdbsum/5f61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f61 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ember, S W]] | |||
[[Category: Schonbrunn, E]] | |||
[[Category: Zhu, J Y]] | |||
[[Category: Cap]] | |||
[[Category: Cell cycle]] | |||
[[Category: Hunk1]] | |||
[[Category: Inhibitor]] | |||
[[Category: Mcap]] | |||
[[Category: Mitotic chromosome associated protein]] | |||
[[Category: Protein binding-inhibitor complex]] | |||
[[Category: Romodomain]] | |||
[[Category: Transcription-transcription inhibitor complex]] | |||
Revision as of 09:21, 10 March 2017
Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-1
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