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| | | #REDIRECT [[5mz4]] This PDB entry is obsolete and replaced by 5mz4 |
| ==Crystal Structure of full-lengh CSFV NS3/4A==
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| <StructureSection load='5lkl' size='340' side='right' caption='[[5lkl]], [[Resolution|resolution]] 3.05Å' scene=''>
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| == Structural highlights ==
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| <table><tr><td colspan='2'>[[5lkl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LKL FirstGlance]. <br>
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| </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lkl OCA], [http://pdbe.org/5lkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lkl RCSB], [http://www.ebi.ac.uk/pdbsum/5lkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lkl ProSAT]</span></td></tr>
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| </table>
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| == Function ==
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| [[http://www.uniprot.org/uniprot/POLG_CSFVA POLG_CSFVA]] E(rns), E1 and E2 are responsible of cell attachment and subsequent fusion of viral and cellular membrane. P7 forms a leader sequence to properly orient NS2 in the membrane. Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.[PROSITE-ProRule:PRU01029] NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity. RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.[PROSITE-ProRule:PRU00539]
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| __TOC__
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| </StructureSection>
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| [[Category: Rey, F A]]
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| [[Category: Tortorici, M A]]
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| [[Category: Viral protease/helicase with its cofactor]]
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| [[Category: Viral protein]]
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