5i09: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5i09 is ~~ON HOLD until Paper Publication~~

==tRNA guanine transglycosylase (TGT) in soaked complex with Furanoside-Based lin-Benzoguanine 3==

~~Authors~~: ~~Ehrmann~~, F.R., ~~Heine~~, A., ~~Klebe~~, G.

== Structural highlights ==

<table><tr><td colspan='2'>[[5i09]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I09 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I09 FirstGlance].

~~Description~~: ~~tRNA~~ guanine ~~transglycosylase~~ (~~TGT~~) in ~~soaked complex with Furanoside~~-~~Based lin~~-~~Benzoguanine 3~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=1UD:METHYL+6-[6-AMINO-2-(METHYLAMINO)-8-OXO-7,8-DIHYDRO-1H-IMIDAZO[4,5-G]QUINAZOLIN-4-YL]-5,6-DIDEOXY-3-O-METHYL-BETA-D-RIBO-HEXOFURANOSIDE'>1UD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i09 OCA], [http://pdbe.org/5i09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i09 RCSB], [http://www.ebi.ac.uk/pdbsum/5i09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i09 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

__TOC__

</StructureSection>

[[Category: Ehrmann, F R]]

[[Category: Heine, A]]

[[Category: Klebe, G]]

[[Category: ~~Ehrmann, F.R~~]]

[[Category: Shigellosis]]

[[Category: ~~Heine, A~~]]

[[Category: Soaking]]

[[Category: Transferase]]

[[Category: Transferase inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5i09 is ON HOLD  until Paper Publication
+==tRNA guanine transglycosylase (TGT) in soaked complex with Furanoside-Based lin-Benzoguanine 3==
+<StructureSection load='5i09' size='340' side='right' caption='[[5i09]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
-Authors: Ehrmann, F.R., Heine, A., Klebe, G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5i09]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I09 FirstGlance]. <br>
-Description: tRNA guanine transglycosylase (TGT) in soaked complex with Furanoside-Based lin-Benzoguanine 3
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1UD:METHYL+6-[6-AMINO-2-(METHYLAMINO)-8-OXO-7,8-DIHYDRO-1H-IMIDAZO[4,5-G]QUINAZOLIN-4-YL]-5,6-DIDEOXY-3-O-METHYL-BETA-D-RIBO-HEXOFURANOSIDE'>1UD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kwo|4kwo]], [[4leq|4leq]], [[4puk|4puk]], [[5i00|5i00]], [[5i02|5i02]], [[5i03|5i03]], [[5i06|5i06]], [[5i07|5i07]], [[3eos|3eos]], [[3ge7|3ge7]], [[1y5x|1y5x]], [[1y5w|1y5w]], [[1y5v|1y5v]], [[4fsa|4fsa]], [[4fr6|4fr6]], [[1p0d|1p0d]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i09 OCA], [http://pdbe.org/5i09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i09 RCSB], [http://www.ebi.ac.uk/pdbsum/5i09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i09 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
+__TOC__
+</StructureSection>
+[[Category: Ehrmann, F R]]
+[[Category: Heine, A]]
 [[Category: Klebe, G]]
-[[Category: Ehrmann, F.R]]
+[[Category: Shigellosis]]
-[[Category: Heine, A]]
+[[Category: Soaking]]
+[[Category: Transferase]]
+[[Category: Transferase inhibitor]]