5mmu: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5mmu is ~~ON HOLD until Paper~~ Publication

==NMR solution structure of the major apple allergen Mal d 1==

== Structural highlights ==

<table><tr><td colspan='2'>[[5mmu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MMU FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmu OCA], [http://pdbe.org/5mmu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mmu RCSB], [http://www.ebi.ac.uk/pdbsum/5mmu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmu ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

More than 70% of birch pollen-allergic patients develop allergic cross-reactions to the major allergen found in apple fruits (Malus domestica), the 17.5 kDa protein Mal d 1. Allergic reactions against this protein result from initial sensitization to the major allergen from birch pollen, Bet v 1. Immunologic cross-reactivity of Bet v 1-specific IgE antibodies with Mal d 1 after apple consumption can subsequently provoke severe oral allergic syndromes. This study presents the three-dimensional NMR solution structure of Mal d 1 (isoform Mal d 1.0101, initially cloned from 'Granny Smith' apples). This protein is composed of a seven-stranded antiparallel beta-sheet and three alpha-helices that form a large internal cavity, similar to Bet v 1 and other cross-reactive food allergens. The Mal d 1 structure provides the basis for elucidating the details of allergic cross-reactivity between birch pollen and apple allergens on a molecular level.

~~Authors:~~ Ahammer, L., Grutsch, S., Kamenik, A.S.~~, Liedl, K~~.R., ~~Tollinger, M~~.

Structure of the Major Apple Allergen Mal d 1.,Ahammer L, Grutsch S, Kamenik AS, Liedl KR, Tollinger M J Agric Food Chem. 2017 Mar 1;65(8):1606-1612. doi: 10.1021/acs.jafc.6b05752., Epub 2017 Feb 15. PMID:28161953<ref>PMID:28161953</ref>

~~Description: NMR solution structure~~ of the ~~major apple allergen Mal d 1~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~[[Category~~: ~~Unreleased Structures]]~~

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Ahammer, L]]

[[Category: Grutsch, S]]

[[Category: Kamenik, A S]]

[[Category: Liedl, K R]]

[[Category: Tollinger, M]]

[[Category: ~~Kamenik, A.S~~]]

[[Category: Allergen]]

[[Category: ~~Grutsch, S]]~~

[[Category: Pr-10 protein apple allergen]]

~~[[Category: Liedl, K.R~~]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5mmu is ON HOLD  until Paper Publication
+==NMR solution structure of the major apple allergen Mal d 1==
+<StructureSection load='5mmu' size='340' side='right' caption='[[5mmu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5mmu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MMU FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmu OCA], [http://pdbe.org/5mmu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mmu RCSB], [http://www.ebi.ac.uk/pdbsum/5mmu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmu ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+More than 70% of birch pollen-allergic patients develop allergic cross-reactions to the major allergen found in apple fruits (Malus domestica), the 17.5 kDa protein Mal d 1. Allergic reactions against this protein result from initial sensitization to the major allergen from birch pollen, Bet v 1. Immunologic cross-reactivity of Bet v 1-specific IgE antibodies with Mal d 1 after apple consumption can subsequently provoke severe oral allergic syndromes. This study presents the three-dimensional NMR solution structure of Mal d 1 (isoform Mal d 1.0101, initially cloned from 'Granny Smith' apples). This protein is composed of a seven-stranded antiparallel beta-sheet and three alpha-helices that form a large internal cavity, similar to Bet v 1 and other cross-reactive food allergens. The Mal d 1 structure provides the basis for elucidating the details of allergic cross-reactivity between birch pollen and apple allergens on a molecular level.
-Authors: Ahammer, L., Grutsch, S., Kamenik, A.S., Liedl, K.R., Tollinger, M.
+Structure of the Major Apple Allergen Mal d 1.,Ahammer L, Grutsch S, Kamenik AS, Liedl KR, Tollinger M J Agric Food Chem. 2017 Mar 1;65(8):1606-1612. doi: 10.1021/acs.jafc.6b05752., Epub 2017 Feb 15. PMID:28161953<ref>PMID:28161953</ref>
-Description: NMR solution structure of the major apple allergen Mal d 1
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 5mmu" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Ahammer, L]]
+[[Category: Grutsch, S]]
+[[Category: Kamenik, A S]]
+[[Category: Liedl, K R]]
 [[Category: Tollinger, M]]
-[[Category: Kamenik, A.S]]
+[[Category: Allergen]]
-[[Category: Grutsch, S]]
+[[Category: Pr-10 protein apple allergen]]
-[[Category: Liedl, K.R]]