5jcd: Difference between revisions
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==Crystal structure of OsCEBiP== | |||
<StructureSection load='5jcd' size='340' side='right' caption='[[5jcd]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jcd]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JCD FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jce|5jce]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jcd OCA], [http://pdbe.org/5jcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jcd RCSB], [http://www.ebi.ac.uk/pdbsum/5jcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jcd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CEBIP_ORYSJ CEBIP_ORYSJ]] Chitin elicitor-binding protein involved in the perception and transduction of chitin oligosaccharide elicitor signal for defense responses.<ref>PMID:16829581</ref> <ref>PMID:21070404</ref> <ref>PMID:22891159</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Chitin is the major component of fungal cell wall and serves as a molecular pattern that can be recognized by the receptor OsCEBiP in rice, a lysine motif (LysM) receptor-like protein (RLP), to trigger immune responses. The molecular mechanisms underlying chitin recognition remain elusive. Here we report the crystal structures of the ectodomain of OsCEBiP (OsCEBiP-ECD) in free and chitin-bound forms. The structures reveal that OsCEBiP-ECD contains three tandem LysMs followed by a novel structure fold of cysteine-rich domain. The structures showed that chitin binding induces no striking conformational changes in OsCEBiP. Structural comparison among N-acetylglucosamine (NAG) oligomer-bound LysMs revealed a highly conserved recognition mechanism, which is expected to facilitate study of other LysM-containing proteins for their NAG binding. Modeling study showed that chitin induces OsCEBiP homodimerization in a "sliding mode". Our data provide insights into rice chitin receptor-mediated immunity triggered by fungal cell wall. | |||
Molecular Mechanism for Fungal Cell Wall Recognition by Rice Chitin Receptor OsCEBiP.,Liu S, Wang J, Han Z, Gong X, Zhang H, Chai J Structure. 2016 May 24. pii: S0969-2126(16)30075-2. doi:, 10.1016/j.str.2016.04.014. PMID:27238968<ref>PMID:27238968</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5jcd" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chai, J J]] | |||
[[Category: Liu, S M]] | |||
[[Category: Wang, J Z]] | |||
[[Category: Chitin receptor]] | |||
[[Category: Sugar binding protein]] | |||
