2ncw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 2ncw is ~~ON HOLD until Paper Publication~~

==NMR structure of WWWKYE21 structure in LPS micelles==

~~Authors~~: ~~Datta~~, A., ~~Bhunia~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[2ncw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NCW FirstGlance]. <br>

~~Description~~: ~~NMR structure~~ of ~~WWWKYE21 structure~~ in ~~LPS micelles~~

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ncu|2ncu]], [[2ncv|2ncv]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncw OCA], [http://pdbe.org/2ncw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ncw RCSB], [http://www.ebi.ac.uk/pdbsum/2ncw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncw ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/HEP2_HUMAN HEP2_HUMAN]] Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10) [MIM:[http://omim.org/entry/612356 612356]]. A hemostatic disorder characterized by a tendency to recurrent thrombosis.<ref>PMID:2647747</ref> <ref>PMID:10391209</ref> <ref>PMID:11204559</ref> <ref>PMID:15337701</ref>

== Function ==

[[http://www.uniprot.org/uniprot/HEP2_HUMAN HEP2_HUMAN]] Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.<ref>PMID:1939083</ref> Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.<ref>PMID:1939083</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bhunia, A]]

[[Category: Datta, A]]

[[Category: ~~Bhunia, A~~]]

[[Category: Antimicrobial peptide]]

[[Category: Antimicrobial protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 2ncw is ON HOLD  until Paper Publication
+==NMR structure of WWWKYE21 structure in LPS micelles==
+<StructureSection load='2ncw' size='340' side='right' caption='[[2ncw]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-Authors: Datta, A., Bhunia, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ncw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NCW FirstGlance]. <br>
-Description: NMR structure of WWWKYE21 structure in LPS micelles
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ncu|2ncu]], [[2ncv|2ncv]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncw OCA], [http://pdbe.org/2ncw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ncw RCSB], [http://www.ebi.ac.uk/pdbsum/2ncw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncw ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/HEP2_HUMAN HEP2_HUMAN]] Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10) [MIM:[http://omim.org/entry/612356 612356]]. A hemostatic disorder characterized by a tendency to recurrent thrombosis.<ref>PMID:2647747</ref> <ref>PMID:10391209</ref> <ref>PMID:11204559</ref> <ref>PMID:15337701</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/HEP2_HUMAN HEP2_HUMAN]] Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.<ref>PMID:1939083</ref>   Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.<ref>PMID:1939083</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bhunia, A]]
 [[Category: Datta, A]]
-[[Category: Bhunia, A]]
+[[Category: Antimicrobial peptide]]
+[[Category: Antimicrobial protein]]