5m1w: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "5m1w" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structure of a stable G-hairpin== | |||
<StructureSection load='5m1w' size='340' side='right' caption='[[5m1w]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5m1w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M1W FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m1w OCA], [http://pdbe.org/5m1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m1w RCSB], [http://www.ebi.ac.uk/pdbsum/5m1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m1w ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
In this study, we report the first atomic resolution structure of a stable G-hairpin formed by a natively occurring DNA sequence. An 11-nt long G-rich DNA oligonucleotide, 5'-d(GTGTGGGTGTG)-3', corresponding to the most abundant sequence motif in irregular telomeric DNA from Saccharomyces cerevisiae (yeast), is demonstrated to adopt a novel type of mixed parallel/antiparallel fold-back DNA structure, which is stabilized by dynamic G:G base pairs that transit between N1-carbonyl symmetric and N1-carbonyl, N7-amino base-pairing arrangements. Although the studied sequence first appears to possess a low capacity for base pairing, it forms a thermodynamically stable structure with a rather complex topology that includes a chain reversal arrangement of the backbone in the center of the continuous G-tract and 3'-to-5' stacking of the terminal residues. The structure reveals previously unknown principles of the folding of G-rich oligonucleotides that could be applied to the prediction of natural and/or the design of artificial recognition DNA elements. The structure also demonstrates that the folding landscapes of short DNA single strands is much more complex than previously assumed. | |||
Structure of a Stable G-Hairpin.,Gajarsky M, Zivkovic ML, Stadlbauer P, Pagano B, Fiala R, Amato J, Tomaska L, Sponer J, Plavec J, Trantirek L J Am Chem Soc. 2017 Mar 2. doi: 10.1021/jacs.6b10786. PMID:28217994<ref>PMID:28217994</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5m1w" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Amato, J]] | |||
[[Category: Fiala, R]] | |||
[[Category: Gajarsky, M]] | |||
[[Category: Pagano, B]] | |||
[[Category: Plavec, J]] | |||
[[Category: Sponer, J]] | |||
[[Category: Stadlbauer, P]] | |||
[[Category: Tomaska, L]] | |||
[[Category: Trantirek, L]] | |||
[[Category: Zivkovic, M L]] | |||
[[Category: Dna]] | |||
[[Category: G-hairpin g:g base pairs nmr spectroscopy conformational exchange]] | |||
