Sandbox Reserved 1061

Activated Caspase-6 Text To Be Displayed</scene>

Figure Legend

This Sandbox is Reserved from 02/09/2015, through 05/31/2016 for use in the course "CH462: Biochemistry 2" taught by Geoffrey C. Hoops at the Butler University. This reservation includes Sandbox Reserved 1051 through Sandbox Reserved 1080.

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Human Caspase-6

spinqualitylabelsall models Caspase-6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Caspase-6 dot representation Dot Representation with Amino Acids highlighted 1 Dot Representation with Amino Acids 2 This is a default text for your page '. Click above on edit this page' to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia or to the article describing Jmol to the rescue. Biological Function Caspase-6 is a member of the Cysteine-Aspartic protease family, and involved in apoptosis. It is most notably involved in neurodegenerative diseases, such as Alzheimer's disease and dementia. Structural Overview Inactive State When the protein is in the inactive state it is a Homotetramer. Active State Originally it was thought to be cleaved and activated by a combination of Caspases-3 and -7, but research has shown that Caspase-6 enters the active state by self-cleaving at residue 193 after a sequence of TEVD. The protein then becomes a Tetramer of Dimers. Activated Caspase-6 this shows the protein bound Figure Legend Mechanism of Action Mechanism is unknown as of right now. The active sight is known to be HIS-121, CYS-163, and GLU-174. It is tightly regulated by Zinc binding to an allosteric site. Zinc Ligand(s) The Zinc ligand is known to inhibit the Caspase-6 protein. Other Ligands Other ligands that bind to Caspase-6 are caspase-8, which is activated within the caspase-chain by Caspase 6. After it being activated by Caspase-6, Caspase-8 is then in it's active state. Caspase-6 has been know to be a self-activator, so other Caspase-6 proteins are also known to be ligands that are bound at the active site.

References

This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.