5hnt: Difference between revisions
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==Crystal Structure of AKR1C3 complexed with CAPE== | |||
<StructureSection load='5hnt' size='340' side='right' caption='[[5hnt]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hnt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HNT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=QAP:2-PHENYLETHYL+(2E)-3-(3,4-DIHYDROXYPHENYL)PROP-2-ENOATE'>QAP</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hnu|5hnu]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hnt OCA], [http://pdbe.org/5hnt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hnt RCSB], [http://www.ebi.ac.uk/pdbsum/5hnt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hnt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hu, X]] | |||
[[Category: Li, C]] | |||
[[Category: Zhang, H]] | [[Category: Zhang, H]] | ||
[[Category: Zhao, Y]] | [[Category: Zhao, Y]] | ||
[[Category: | [[Category: Akr1c3]] | ||
[[Category: Cape]] | |||
[[Category: Inhibition]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 21:16, 15 March 2017
Crystal Structure of AKR1C3 complexed with CAPE
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