5j6s: Difference between revisions
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==Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand== | |||
<StructureSection load='5j6s' size='340' side='right' caption='[[5j6s]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5j6s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J6S FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6GA:(2S)-N~1~-BENZYL-2-[(4-FLUOROPHENYL)METHYL]-N~3~-HYDROXYPROPANEDIAMIDE'>6GA</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j6s OCA], [http://pdbe.org/5j6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j6s RCSB], [http://www.ebi.ac.uk/pdbsum/5j6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j6s ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ERAP2_HUMAN ERAP2_HUMAN]] Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.<ref>PMID:12799365</ref> <ref>PMID:15908954</ref> <ref>PMID:16286653</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Deprez-Poulain, R]] | |||
[[Category: Giastas, P]] | [[Category: Giastas, P]] | ||
[[Category: Mpakali, A]] | [[Category: Mpakali, A]] | ||
[[Category: Saridakis, E]] | |||
[[Category: Stratikos, E]] | [[Category: Stratikos, E]] | ||
[[Category: | [[Category: Aminopeptidase]] | ||
[[Category: Endoplasmic reticulum]] | |||
[[Category: Hydrolase]] | |||
[[Category: Zn binding metallopeptidase]] | |||
Revision as of 21:19, 15 March 2017
Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand
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