5tke: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5tke is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal Structure of Eukaryotic Hydrolase==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5tke]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TKE FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tke OCA], [http://pdbe.org/5tke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tke RCSB], [http://www.ebi.ac.uk/pdbsum/5tke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tke ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN]] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Jiang, J]]

[[Category: Li, B]]

[[Category: Hydrolase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5tke is ON HOLD  until Paper Publication
+==Crystal Structure of Eukaryotic Hydrolase==
+<StructureSection load='5tke' size='340' side='right' caption='[[5tke]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5tke]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TKE FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tke OCA], [http://pdbe.org/5tke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tke RCSB], [http://www.ebi.ac.uk/pdbsum/5tke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tke ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN]] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref>   Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Jiang, J]]
+[[Category: Li, B]]
+[[Category: Hydrolase]]