Sandbox Reserved 1071: Difference between revisions
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{{Sandbox_Reserved_Butler_CH462_Sp2015_#}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_Butler_CH462_Sp2015_#}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
=DgcZ from ''E. coli''= | =DgcZ from ''E. coli''= | ||
Diguanylate cyclases synthesize cyclic dimeric-GMP (c-di-GMP) from two GTP molecules. [[Image:C-di-GMP.jpg |200 px|left|thumb|cyclic-dimeric-GMP]] C-di-GMP is a second messenger in the production of poly-β-1,6-N-acetylglucosamine (poly-GlcNAc) [[Image:Poly B-1,6 GlcNAc.jpg | | Diguanylate cyclases synthesize cyclic dimeric-GMP (c-di-GMP) from two GTP molecules. [[Image:C-di-GMP.jpg |200 px|left|thumb|cyclic-dimeric-GMP]] C-di-GMP is a second messenger in the production of poly-β-1,6-N-acetylglucosamine (poly-GlcNAc) [[Image:Poly B-1,6 GlcNAc.jpg |200 px|left|thumb|poly-β-1,6-N-acetylglucosamine]] , a polysaccharide required for ''E. coli'' biofilm production. This biofilm allows ''E. coli'' to adhere to extracellular surfaces. The DgcZ protein is made of two domains: the catalytic GGDEF domain responsible for sythnesizing c-di-GMP and the regulatory CZB domain that binds zinc. When zinc is bound, the CZB and GGDEF domains adopt conformations that inhibit DgcZ function.<StructureSection load='4h54' size='300' frame='true' align='right' caption='E. coli Diguanylate cyclase'> | ||
</StructureSection> | </StructureSection> | ||
