5fy5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5fy5 is ~~ON HOLD until Paper Publication~~

==Crystal structure of the catalytic domain of human JARID1B in complex with fumarate==

~~Authors~~: ~~Nowak~~, R., ~~Srikannathasan~~, V., ~~Johansson~~, C., ~~Gileadi~~, C., ~~Kupinska~~, K., ~~Strain~~-~~Damerell~~, C., ~~Szykowska~~, A., ~~Von Delft~~, F., ~~Burgess~~-~~Brown, N~~.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., ~~Oppermann, U.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5fy5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FY5 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FY5 FirstGlance].

~~Description~~: ~~Crystal structure of the catalytic domain of human JARID1B in complex with fumarate~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FUM:FUMARIC+ACID'>FUM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fy5 OCA], [http://pdbe.org/5fy5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fy5 RCSB], [http://www.ebi.ac.uk/pdbsum/5fy5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fy5 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Burgess-Brown, N A]]

[[Category: Delft, F Von]]

[[Category: Edwards, A M]]

[[Category: Gileadi, C]]

[[Category: Johansson, C]]

[[Category: Kupinska, K]]

[[Category: Nowak, R]]

~~[[Category: Arrowsmith, C.H]]~~

~~[[Category: Gileadi, C]]~~

[[Category: Oppermann, U]]

[[Category: Srikannathasan, V]]

[[Category: Strain-Damerell, C]]

[[Category: Szykowska, A]]

[[Category: ~~Burgess-Brown, N.A~~]]

[[Category: Jarid1b]]

[[Category: ~~Von Delft, F~~]]

[[Category: Oxidoreductase]]

[[Category: ~~Edwards, A.M~~]]

[[Category: Plu1]]

[[Category: ~~Johansson, C]]~~

[[Category: Tca intermediate]]

~~[[Category: Strain-Damerell, C]]~~

~~[[Category: Srikannathasan, V]]~~

~~[[Category: Bountra, C]]~~

~~[[Category: Kupinska, K~~]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5fy5 is ON HOLD  until Paper Publication
+==Crystal structure of the catalytic domain of human JARID1B in complex with fumarate==
+<StructureSection load='5fy5' size='340' side='right' caption='[[5fy5]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
-Authors: Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fy5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FY5 FirstGlance]. <br>
-Description: Crystal structure of the catalytic domain of human JARID1B in complex with fumarate
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FUM:FUMARIC+ACID'>FUM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fxv|5fxv]], [[5fxw|5fxw]], [[5fxx|5fxx]], [[5fxz|5fxz]], [[5fy0|5fy0]], [[5fy1|5fy1]], [[5fy4|5fy4]], [[5fy7|5fy7]], [[5fy8|5fy8]], [[5fy9|5fy9]], [[5fyb|5fyb]], [[5fyc|5fyc]], [[5fyh|5fyh]], [[5fyi|5fyi]], [[5fym|5fym]], [[5fys|5fys]], [[5fyt|5fyt]], [[5fyu|5fyu]], [[5fyv|5fyv]], [[5fyy|5fyy]], [[5fyz|5fyz]], [[5fz0|5fz0]], [[5fz1|5fz1]], [[5fz3|5fz3]], [[5fz4|5fz4]], [[5fz6|5fz6]], [[5fz7|5fz7]], [[5fz8|5fz8]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fy5 OCA], [http://pdbe.org/5fy5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fy5 RCSB], [http://www.ebi.ac.uk/pdbsum/5fy5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fy5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Burgess-Brown, N A]]
+[[Category: Delft, F Von]]
+[[Category: Edwards, A M]]
+[[Category: Gileadi, C]]
+[[Category: Johansson, C]]
+[[Category: Kupinska, K]]
 [[Category: Nowak, R]]
-[[Category: Arrowsmith, C.H]]
-[[Category: Gileadi, C]]
 [[Category: Oppermann, U]]
+[[Category: Srikannathasan, V]]
+[[Category: Strain-Damerell, C]]
 [[Category: Szykowska, A]]
-[[Category: Burgess-Brown, N.A]]
+[[Category: Jarid1b]]
-[[Category: Von Delft, F]]
+[[Category: Oxidoreductase]]
-[[Category: Edwards, A.M]]
+[[Category: Plu1]]
-[[Category: Johansson, C]]
+[[Category: Tca intermediate]]
-[[Category: Strain-Damerell, C]]
-[[Category: Srikannathasan, V]]
-[[Category: Bountra, C]]
-[[Category: Kupinska, K]]