5l7r: Difference between revisions
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==Crystal structure of BvGH123== | |||
<StructureSection load='5l7r' size='340' side='right' caption='[[5l7r]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5l7r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L7R FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7r OCA], [http://pdbe.org/5l7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l7r RCSB], [http://www.ebi.ac.uk/pdbsum/5l7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7r ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Bacteroides vulgatus is a member of the human microbiota whose abundance is increased in patients with Crohn's disease. We show that a B. vulgatus glycoside hydrolase from the carbohydrate active enzyme family GH123, BvGH123, is an N-acetyl-beta-galactosaminidase that acts with retention of stereochemistry, and, through a 3-D structure in complex with Gal-thiazoline, provide evidence in support of a neighbouring group participation mechanism. | |||
Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-beta-galactosaminidase that uses neighbouring group participation.,Roth C, Petricevic M, John A, Goddard-Borger ED, Davies GJ, Williams SJ Chem Commun (Camb). 2016 Sep 25;52(74):11096-9. doi: 10.1039/c6cc04649e. Epub, 2016 Aug 22. PMID:27546776<ref>PMID:27546776</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5l7r" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Davies, G J]] | |||
[[Category: Goddard-Borger, E D]] | |||
[[Category: John, A]] | |||
[[Category: Petricevic, M]] | |||
[[Category: Roth, C]] | |||
[[Category: Williams, S J]] | |||
[[Category: Bacon]] | |||
[[Category: Hydrolase]] | |||
[[Category: Tim barrel]] | |||
