5tda: Difference between revisions
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==Crystal structure of the UBR-box domain from UBR2 in complex with RLWS N-degron== | |||
<StructureSection load='5tda' size='340' side='right' caption='[[5tda]], [[Resolution|resolution]] 0.79Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5tda]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TDA FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tdb|5tdb]], [[5tdc|5tdc]], [[5tdd|5tdd]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tda OCA], [http://pdbe.org/5tda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tda RCSB], [http://www.ebi.ac.uk/pdbsum/5tda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tda ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/UBR2_HUMAN UBR2_HUMAN]] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.<ref>PMID:15548684</ref> <ref>PMID:20298436</ref> <ref>PMID:20835242</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gehring, K]] | |||
[[Category: Kozlov, G]] | |||
[[Category: Munoz-Escobar, J]] | |||
[[Category: Ligase]] | |||
[[Category: N-degron]] | |||
[[Category: N-end rule]] | |||
[[Category: Ubr-box]] | |||
[[Category: Zn-finger]] | |||
Revision as of 16:45, 22 March 2017
Crystal structure of the UBR-box domain from UBR2 in complex with RLWS N-degron
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