Chaperonin

spinqualitylabelsall models E. coli GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions (PDB entry 1pcq) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Crystal Structure of Chaperonin, 1pcq Chaperonins (CPN) are oligomeric proteins that mediate the folding of polypeptide chains. Group I CPN are found in bacteria, chloroplasts and mitochondria. For an introductory overview, see Chaperonins in Wikipedia. The most characterized CPN are in the GroEL/GroES complex from Escherichia coli and CPN60/CPN10 from Thermus thermophilus. The larger subunit (GroEL, CPN60) contains 3 domains: apical, intermediate and equatorial domain. The apical domain is the one which binds the polypeptide substrate. The equatorial domains binds the nucleotide. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya. E. coli GroEL/GroES complex (GroEL in green, GroES in magenta, PDB entry 1pcq). GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions. See also Chaperones. For GroEl in Hebrew see Sand box groel.

3D Structures of Chaperonin

Updated on 02-April-2017

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• Group I
• Large subunit
  • 1pcq – MtGroEL1 apical domain – Mycobacterium tuberculosis
    
  • 1pcq, Chaperones – MtGroEL2 residues 42-539
    
  • Sand box groel, 4v43, 1oel, 1grl, 2yey, 4wsc, 4wgl – EcGroEL (mutant) - Escherichia coli
    
  • 3e76, 2nwc, 1xck, 1ss8, 4hel – EcGroEL
    
  • 3c9v, 3cau, 2ynj – EcGroEL – Cryo EM
    
  • 2c7e, 1gr5, 4aaq - EcGroEL (mutant) – Cryo EM
    
  • 1dk7, 1la1 - EcGroEL apical domain
    
  • 1fy9, 1fya, 1kid, 1jon, 3vz6, 3vz7, 3vz8 – EcGroEL apical domain (mutant)
    
  • 1srv – TtCPN60 apical domain - Thermus thermophilus
    
  • 3osx - CPN60 apical domain – Xenorhabdus nematophila
    
  • 1iok – CPN60 – Paracoccus denitrificans
    
  • 5da8 - GroEL – Chlorobium tepidum
    
  • 5cdk, 5cdj - GroEL apical domain – Chlamydomonas reinhardtii
    
• Large subunit binary complex
  • 1kp8 - EcGroEL (mutant) + ATP
    
  • 4aar, 4aas, 4aau, 4ab2, 4ab3 - EcGroEL (mutant) + ATP – Cryo EM
    
  • 1sx3 - EcGroEL + ATP
    
  • 1sx4 - EcGroEL + ADP
    
  • 4ki8 - EcGroEL (mutant) + ADP
    
  • 1mnf – EcGroEL + polypeptide
    
  • 2cgt – EcGroEL + capsid assbly protein GP31 – EM
    
  • 1dkd - EcGroEL apical domain + polypeptide
    
  • 4pj1 - GroEL + ADP – human
    
• Small subunit
  • 3nx6 – GroES residues 40-134 (mutant) – Xanthomonas oryzae
    
  • 1wnr – TtCPN10 residues 1-94
    
  • 1p3h, 1hx5 – MtCPN10
    
  • 1p82, 1p83 - MtCPN10 residues 1-25 - NMR
    
  • 1egs - GroES residues 19-27 - NMR
• Large + small subunit
  • 1svt, 1pcq - EcGroEL + GroES
    
  • 1pf9, 1aon, 4pko - EcGroEL + GroES + ADP
    
  • 3wvl - EcGroEL (mutant) + GroES + ATP
    
  • 2c7c, 2c7d - EcGroEL + GroES – Cryo EM
    
  • 1gru - EcGroEL + GroES + ATP + ADP – Cryo EM
    
  • 3zpz, 3zq0, 3zq1 - EcGroEL + GroES + ADP – Cryo EM
    
  • 1we3 – TtCPN60 + CPN10
    
  • 1wf4, 4v4o, 4pkn - TtCPN60 + CPN10 + ADP
• Group II
  • 3izh, 3izi, 3izj, 3izk, 3izl, 3izm, 3izn, 3los, 3iyf, 3j3x – MmCPN – Methanococcus maripaludis – EM
    
  • 3kfb, 3kfe, 3kfk – MmCPN
    
  • 3j02, 3j03 – MmCPN (mutant) – Cryo EM
    
  • 3ruq - MmCPN + ADP
    
  • 3rus - MmCPN (mutant) + ADP
    
  • 3ruw - MmCPN (mutant) + ADP-AlF3
    
  • 3ruv - MmCPN (mutant) + ATP analog
    
• CCT
  • 2xsm, 4b2t – bCPN CCT – bovine
    
  • 4v81, 4v94, 4v8r – CPN CCT - yeast
    
  • 3iyg, 4a0o - bCPN CCT – Cryo EM
    
  • 4a0v - bCPN CCT + AMPPNP – Cryo EM
    
  • 4a0w - bCPN CCT + ADP + AlF3 – Cryo EM
    
  • 4a13 - bCPN CCT + ADP – Cryo EM
    
  • 3ktt - bCPN CCT β subunit – Cryo EM
    
  • 1gml, 1gn1 - CPN CCT γ subunit apical domain – mouse
• Hsp33

See Heat Shock Proteins

• Thermosome
  • 1a6d - TaTherm α+β subunits – Thermoplasma acidophilum
    
  • 1a6e - TaTherm α+β subunits + ADP
    
  • 1ass, 1asx - TaTherm α apical domain
    
  • 1e0r – TaTherm β apical domain
    
  • 3ko1 – AtTherm α subunit– Acidianus tengchongensis
    
  • 3j1b, 3j1c, 3j1e - AtTherm α subunit – Cryo EM
    
  • 3j1f - AtTherm β subunit + ATP – Cryo EM
    
  • 3aq1 – Therm – Methanococcoides burtonii
    
  • 1q2v, 1q3r – TkTherm α subunit (mutant) – Thermococcus KS-1
    
  • 1q3q - TkTherm α subunit (mutant) + AMP-PNP
    
  • 1q3s - TkTherm α subunit (mutant) + ADP
    
  • 4xcd - SsTherm β subunit + ADP – Sulfolobus solfataricus
    
  • 4xcg, 4xci - SsTherm α+β subunits + ADP
    
  • 1lep – CPN-10 – Mycobacterium leprae

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Eric Martz, Joel L. Sussman