5n0h: Difference between revisions
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==Crystal structure of NDM-1 in complex with hydrolyzed meropenem - new refinement== | |||
<StructureSection load='5n0h' size='340' side='right' caption='[[5n0h]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5n0h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N0H FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8FB:(3~{S},4~{R},5~{S})-5-[(2~{S},3~{R})-1,3-BIS(OXIDANYL)-1-OXIDANYLIDENE-BUTAN-2-YL]-3-[(3~{S},5~{S})-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL-4-METHYL-PYRROLIDINE-2-CARBOXYLIC+ACID'>8FB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | ||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eyl|4eyl]]</td></tr> | ||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n0h OCA], [http://pdbe.org/5n0h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n0h RCSB], [http://www.ebi.ac.uk/pdbsum/5n0h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n0h ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Beta-lactamase]] | |||
[[Category: Jaskolski, M]] | |||
[[Category: King, D T]] | |||
[[Category: Minor, W]] | |||
[[Category: Raczynska, J E]] | |||
[[Category: Shabalin, I G]] | |||
[[Category: Strynadka, N C.J]] | |||
[[Category: Wlodawer, A]] | [[Category: Wlodawer, A]] | ||
[[Category: | [[Category: Hydrolase-antibiotic complex]] | ||
[[Category: | [[Category: Metallo-beta-lactamase]] | ||
[[Category: | [[Category: Ndm-1]] | ||
Revision as of 13:29, 5 April 2017
Crystal structure of NDM-1 in complex with hydrolyzed meropenem - new refinement
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