5upy: Difference between revisions

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'''Unreleased structure'''


The entry 5upy is ON HOLD
==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Listeria Monocytogenes in the complex with IMP and Q21==
 
<StructureSection load='5upy' size='340' side='right' caption='[[5upy]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
Authors: Kim, Y., Makowska-Grzyska, M., Osipiuk, J., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5upy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UPY FirstGlance]. <br>
Description: Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Listeria Monocytogenes in the complex with IMP and Q21
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=Q21:(2S)-2-(NAPHTHALEN-1-YLOXY)-N-[2-(PYRIDIN-4-YL)-1,3-BENZOXAZOL-5-YL]PROPANAMIDE'>Q21</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5upx|5upx]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5upy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5upy OCA], [http://pdbe.org/5upy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5upy RCSB], [http://www.ebi.ac.uk/pdbsum/5upy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5upy ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/Q926Y9_LISMO Q926Y9_LISMO]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
__TOC__
</StructureSection>
[[Category: IMP dehydrogenase]]
[[Category: Anderson, W F]]
[[Category: Structural genomic]]
[[Category: Joachimiak, A]]
[[Category: Kim, Y]]
[[Category: Makowska-Grzyska, M]]
[[Category: Makowska-Grzyska, M]]
[[Category: Joachimiak, A]]
[[Category: Anderson, W.F]]
[[Category: Osipiuk, J]]
[[Category: Osipiuk, J]]
[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
[[Category: Csgid]]
[[Category: Kim, Y]]
[[Category: Delta cb]]
[[Category: Impdh]]
[[Category: Oxidoreductase]]
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