5mgj: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5mgj is ~~ON HOLD until Paper Publication~~

==Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridine derivative 1==

~~Authors~~: ~~Lolli~~, G., ~~Spiliotopoulos~~, D., ~~Caflisch~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5mgj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MGJ OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MGJ FirstGlance].

~~Description~~: ~~Crystal Structure~~ of ~~BAZ2A bromodomain in~~ complex with 1-~~methylpyridine derivative 1~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=7MX:ETHYL+4-CHLORANYL-1-METHYL-6-OXIDANYLIDENE-PYRIDINE-3-CARBOXYLATE'>7MX</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5mge|5mge]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mgj OCA], [http://pdbe.org/5mgj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mgj RCSB], [http://www.ebi.ac.uk/pdbsum/5mgj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mgj ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).

__TOC__

</StructureSection>

[[Category: Caflisch, A]]

[[Category: Lolli, G]]

[[Category: Spiliotopoulos, D]]

[[Category: ~~Caflisch, A~~]]

[[Category: Four helical bundle]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5mgj is ON HOLD  until Paper Publication
+==Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridine derivative 1==
+<StructureSection load='5mgj' size='340' side='right' caption='[[5mgj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors: Lolli, G., Spiliotopoulos, D., Caflisch, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5mgj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MGJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MGJ FirstGlance]. <br>
-Description: Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridine derivative 1
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7MX:ETHYL+4-CHLORANYL-1-METHYL-6-OXIDANYLIDENE-PYRIDINE-3-CARBOXYLATE'>7MX</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5mge|5mge]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mgj OCA], [http://pdbe.org/5mgj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mgj RCSB], [http://www.ebi.ac.uk/pdbsum/5mgj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mgj ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Caflisch, A]]
 [[Category: Lolli, G]]
 [[Category: Spiliotopoulos, D]]
-[[Category: Caflisch, A]]
+[[Category: Four helical bundle]]
+[[Category: Transcription]]