5h1i: Difference between revisions
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==NMR structure of TIBA, a chimera of SFTI== | |||
<StructureSection load='5h1i' size='340' side='right' caption='[[5h1i]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5h1i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H1I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H1I FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h1h|5h1h]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h1i OCA], [http://pdbe.org/5h1i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h1i RCSB], [http://www.ebi.ac.uk/pdbsum/5h1i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h1i ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
An orally active and metabolically stable peptide TIBA was successfully engineered as a chimera by fusing an analgesic bradykinin receptor antagonist peptide and the trypsin inhibitory loop of sunflower trypsin inhibitor-1. As a fusion cyclic peptide, the metabolically labile analgesic peptide is protected from degradation by exopeptidases as well as the endopeptidases, and its serum half-life extended from <5 min to >6 h as a chimera. Moreover, the chimera TIBA was also found to be orally active in an animal pain model using a hot plate assay. | |||
An Orally Active Bradykinin B1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor.,Qiu Y, Taichi M, Wei N, Yang H, Luo KQ, Tam JP J Med Chem. 2017 Jan 12;60(1):504-510. doi: 10.1021/acs.jmedchem.6b01011. Epub, 2016 Dec 15. PMID:27977181<ref>PMID:27977181</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5h1i" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Tam, J P]] | |||
[[Category: Xiao, T]] | [[Category: Xiao, T]] | ||
[[Category: | [[Category: Chimera]] | ||
[[Category: Cyclic peptide]] | |||
[[Category: De novo protein]] | |||
[[Category: Sunflower trypsin inhibitor]] | |||
[[Category: Tiba]] | |||
Revision as of 12:57, 19 April 2017
NMR structure of TIBA, a chimera of SFTI
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