5llm: Difference between revisions
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The entry | ==Structure of the thermostabilized EAAT1 cryst mutant in complex with L-ASP and the allosteric inhibitor UCPH101== | ||
<StructureSection load='5llm' size='340' side='right' caption='[[5llm]], [[Resolution|resolution]] 3.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5llm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LLM FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6Z6:2-AMINO-5,6,7,8-TETRAHYDRO-4-(4-METHOXYPHENYL)-7-(NAPHTHALEN-1-YL)-5-OXO-4H-CHROMENE-3-CARBONITRILE'>6Z6</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5llm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5llm OCA], [http://pdbe.org/5llm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5llm RCSB], [http://www.ebi.ac.uk/pdbsum/5llm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5llm ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/EAA1_HUMAN EAA1_HUMAN]] Alternating hemiplegia of childhood;Episodic ataxia type 6. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/EAA1_HUMAN EAA1_HUMAN]] Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Assal, R]] | |||
[[Category: Canul-Tec, J]] | |||
[[Category: Legrand, P]] | |||
[[Category: Reyes, N]] | |||
[[Category: Excitatory amino acid transporter 1]] | |||
[[Category: Human glutamate transporter]] | |||
[[Category: Slc1a3]] | |||
[[Category: Transport protein]] | |||
[[Category: Ucph101]] | |||
Revision as of 12:59, 19 April 2017
Structure of the thermostabilized EAAT1 cryst mutant in complex with L-ASP and the allosteric inhibitor UCPH101
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