Vytorin: Difference between revisions
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When administered, the drug is inactive until it is absorbed. Upon absorption ezetimibe is conjugated to active phenolic glucuronide where it is metabolized within the small intestine and liver. <ref>https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021445s019lbl.pdf</ref> Ezetimibe limits the internalization of cholesterol by the small intestine. Cholesterol is absorbed into cells with NPC1L1 through clathrin/AP2-mediated endocytosis. AP2 is a multimeric protein that works on the cell membrane to facilitate endocytosis. Ezetimibe inhibits the absorption of cholesterol by blocking the internalization of NPC1L1. <ref>https://www.ncbi.nlm.nih.gov/pubmed/18522832</ref> | When administered, the drug is inactive until it is absorbed. Upon absorption ezetimibe is conjugated to active phenolic glucuronide where it is metabolized within the small intestine and liver. <ref>https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021445s019lbl.pdf</ref> Ezetimibe limits the internalization of cholesterol by the small intestine. Cholesterol is absorbed into cells with NPC1L1 through clathrin/AP2-mediated endocytosis. AP2 is a multimeric protein that works on the cell membrane to facilitate endocytosis. Ezetimibe inhibits the absorption of cholesterol by blocking the internalization of NPC1L1. <ref>https://www.ncbi.nlm.nih.gov/pubmed/18522832</ref> | ||
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<b>Simvastatin</b> | <b>Simvastatin</b> | ||
