Vytorin: Difference between revisions

Line 8:

Ezetimibe works to selectively inhibit cholesterol and phytosterol absorption in the body’s intestines. This drug appears to work at the brush border of the small intestine inhibiting cholesterol absorption which then leads to a decrease in cholesterol delivery to the liver. This is different from other cholesterol-reducing compounds because it does not directly inhibit cholesterol synthesis in the liver.<ref>https://www.drugbank.ca/drugs/DB00973</ref> By inhibiting the absorption of cholesterol, ezetimibe decreases the cholesterol levels in the blood. <ref>https://pubchem.ncbi.nlm.nih.gov/compound/Ezetimibe#section=Experimental-Properties</ref>. Ezetimibe specifically targets the sterol transporter, <scene name='75/757901/Npc1l1_transporter/2'>Niemann-Pick C1-Like1 (NPC1L1)</scene> which controls cholesterol uptake at the jejunal enterocyte brush border.

<b>Simvastatin</b>

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

Revision as of 20:41, 19 April 2017 view source Carley Sadler (talk \| contribs) 34 edits No edit summary ← Older edit		Revision as of 20:48, 19 April 2017 view source Carley Sadler (talk \| contribs) 34 edits No edit summary Newer edit →
Line 8:		Line 8:

	Ezetimibe works to selectively inhibit cholesterol and phytosterol absorption in the body’s intestines. This drug appears to work at the brush border of the small intestine inhibiting cholesterol absorption which then leads to a decrease in cholesterol delivery to the liver. This is different from other cholesterol-reducing compounds because it does not directly inhibit cholesterol synthesis in the liver.<ref>https://www.drugbank.ca/drugs/DB00973</ref> By inhibiting the absorption of cholesterol, ezetimibe decreases the cholesterol levels in the blood. <ref>https://pubchem.ncbi.nlm.nih.gov/compound/Ezetimibe#section=Experimental-Properties</ref>. Ezetimibe specifically targets the sterol transporter, <scene name='75/757901/Npc1l1_transporter/2'>Niemann-Pick C1-Like1 (NPC1L1)</scene> which controls cholesterol uptake at the jejunal enterocyte brush border.		Ezetimibe works to selectively inhibit cholesterol and phytosterol absorption in the body’s intestines. This drug appears to work at the brush border of the small intestine inhibiting cholesterol absorption which then leads to a decrease in cholesterol delivery to the liver. This is different from other cholesterol-reducing compounds because it does not directly inhibit cholesterol synthesis in the liver.<ref>https://www.drugbank.ca/drugs/DB00973</ref> By inhibiting the absorption of cholesterol, ezetimibe decreases the cholesterol levels in the blood. <ref>https://pubchem.ncbi.nlm.nih.gov/compound/Ezetimibe#section=Experimental-Properties</ref>. Ezetimibe specifically targets the sterol transporter, <scene name='75/757901/Npc1l1_transporter/2'>Niemann-Pick C1-Like1 (NPC1L1)</scene> which controls cholesterol uptake at the jejunal enterocyte brush border.


	<b>Simvastatin</b>		<b>Simvastatin</b>