Follitropin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 10: | Line 10: | ||
== Side Effects <ref>Follistim AQ Side Effects in Detail. (n.d.). Retrieved April 18, 2017, from https://www.drugs.com/sfx/follistim-aq-side-effects.html</ref>== | == Side Effects <ref>Follistim AQ Side Effects in Detail. (n.d.). Retrieved April 18, 2017, from https://www.drugs.com/sfx/follistim-aq-side-effects.html</ref>== | ||
Possible side effects from this drug include abnormal ovarian enlargement, Ovarian Hyperstimulation Syndrome (OHSS), spontaneous abortion, severe abdominal/stomach pain, bloating and rapid weight gain, nausea, and vomiting. Less common side effects include heavy non-menstrual vaginal bleeding, unusual tiredness and/or weakness, increased heart rate, and swelling of the breasts | Possible side effects from this drug include abnormal ovarian enlargement, Ovarian Hyperstimulation Syndrome (OHSS), spontaneous abortion, severe abdominal/stomach pain, bloating and rapid weight gain, nausea, and vomiting. Less common side effects include heavy non-menstrual vaginal bleeding, unusual tiredness and/or weakness, increased heart rate, and swelling of the breasts | ||
== Structure == | == Structure <ref>DrugBank (Ed.). (2017, April 17). Follitropin beta. In DrugBank. Retrieved from https://www.drugbank.ca/drugs/DB00066</ref>== | ||
The amino acid sequence and structure of follitropin beta are exactly the same as that of human urinary follicle-stimulating hormone (hFSH). Follitropin beta is a glycoprotein hormone that is created through recombinant DNA technology. The dimeric structure of follitropin beta contains 2 glycoprotein subunits – alpha, consisting of 92 amino acids, and beta, consisting of 111 amino acids | The amino acid sequence and structure of follitropin beta are exactly the same as that of human urinary follicle-stimulating hormone (hFSH). Follitropin beta is a glycoprotein hormone that is created through recombinant DNA technology. The dimeric structure of follitropin beta contains 2 glycoprotein subunits – alpha, consisting of 92 amino acids, and beta, consisting of 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. | ||
== Mechanism == | == Mechanism == | ||
Follitropin Beta is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of cells. FSH binds the receptor, FSHR, on the target cell. FSH experiences a conformational change which then allows the sulfotyrosine (sTYS335) on the receptor to bind to the FSH. This activates the transmembrane domain. The activation of this domain causes the enzyme, kinase, to phosphorylate a serine and threonine on the C-terminal end of the receptor using ATP. The newly phosphorylated serine and threonine cause the activation of the signaling molecule PI3K, phosphoinositide-3-kinase. After PI3K is activated, it then activates the APK kinase cascade, leading to different cellular responses. | Follitropin Beta is a form of follicular stimulating hormone (FSH), which acts through a transmembrane G-protein receptor on the surface of cells. FSH binds the receptor, FSHR, on the target cell. FSH experiences a conformational change which then allows the sulfotyrosine (sTYS335) on the receptor to bind to the FSH. This activates the transmembrane domain. The activation of this domain causes the enzyme, kinase, to phosphorylate a serine and threonine on the C-terminal end of the receptor using ATP. The newly phosphorylated serine and threonine cause the activation of the signaling molecule PI3K, phosphoinositide-3-kinase. After PI3K is activated, it then activates the APK kinase cascade, leading to different cellular responses. | ||
