Sandbox Reserved 1069: Difference between revisions

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==Structure==

[[Image:3h90sections.PNG|200px|left|thumb|Figure 1. ~~Protein Orien~~]]

[[Image:3h90sections.PNG|200px|left|thumb|Figure 1. The distribution of YiiP through the membrane is shown. The CTD is shown highlighted in the yellow to show that it is in the cytoplasm and the TMD is highlighted with blue to show that it sits in the membrane]]

YiiP is a homodimer [https://en.wikipedia.org/wiki/Protein_dimer (protein dimer)], with each monomer consisting of 238 residues with TransMembrane (<scene name='69/694236/Realtmd1/1'>TMD</scene>) and C-Terminal (<scene name='69/694236/Realctd1/1'>CTD</scene>) domains (colored blue) that are connected via a charge interlocking mechanism (<scene name='75/756372/Bestsaltbridgetransparent/1'>salt bridge</scene>) located on a flexible loop. In total, the Yiip protein has three Zn2+ <scene name='69/694236/Bindingsiteswcolor/2'>binding sites</scene>, site A, B, and C. Site A is located in the <scene name='69/694236/Bindingsiteswcolor/3'>TMD</scene> of the protein, highlighted in purple, site C is located in the <scene name='69/694236/Bindingsiteswcolor/4'>CTD</scene>, now seen in purple, and site B is located at the junction of the two domains. The TMD, where Zn2+ binding site A resides, consists of 6 transmembrane (TM) helices, 4 of which, <scene name='69/694236/Tmlabels/1'>TM1,TM2,TM4, and TM5</scene> (labeled on only one monomer, but present on both), pivot about the ion binding site A. The remaining two helices, <scene name='69/694236/Tm3tm6/2'>TM3 and TM6</scene>, are oriented <scene name='69/694236/Tm3tm6antiparallel/1'>antiparallel</scene> to the bundle. Movement of these helices plays a role in the function of Zn2+ transport.

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@@ Line 5: / Line 5: @@
 <StructureSection load='Realedited.pdb' size='340' side='right' caption='Zinc Transporter YiiP' scene=''>
 ==Structure==
-[[Image:3h90sections.PNG|200px|left|thumb|Figure 1. Protein Orien]]
+[[Image:3h90sections.PNG|200px|left|thumb|Figure 1. The distribution of YiiP through the membrane is shown. The CTD is shown highlighted in the yellow to show that it is in the cytoplasm and the TMD is highlighted with blue to show that it sits in the membrane]]
 YiiP is a homodimer [https://en.wikipedia.org/wiki/Protein_dimer (protein dimer)], with each monomer consisting of 238 residues with TransMembrane (<scene name='69/694236/Realtmd1/1'>TMD</scene>) and C-Terminal (<scene name='69/694236/Realctd1/1'>CTD</scene>) domains (colored blue) that are connected via a charge interlocking mechanism (<scene name='75/756372/Bestsaltbridgetransparent/1'>salt bridge</scene>) located on a flexible loop. In total, the Yiip protein has three Zn<sup>2+</sup> <scene name='69/694236/Bindingsiteswcolor/2'>binding sites</scene>, site A, B, and C. Site A is located in the <scene name='69/694236/Bindingsiteswcolor/3'>TMD</scene> of the protein, highlighted in purple, site C is located in the <scene name='69/694236/Bindingsiteswcolor/4'>CTD</scene>, now seen in purple, and site B is located at the junction of the two domains. The TMD, where Zn<sup>2+</sup> binding site A resides, consists of 6 transmembrane (TM) helices, 4 of which, <scene name='69/694236/Tmlabels/1'>TM1,TM2,TM4, and TM5</scene> (labeled on only one monomer, but present on both), pivot about the ion binding site A. The remaining two helices, <scene name='69/694236/Tm3tm6/2'>TM3 and TM6</scene>, are oriented <scene name='69/694236/Tm3tm6antiparallel/1'>antiparallel</scene> to the bundle. Movement of these helices plays a role in the function of Zn<sup>2+</sup> transport.