Disintegrin: Difference between revisions
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<StructureSection load='1z1x' size='350' side='right' scene='Disintegrin/Cv/1' caption='Disintegrin, [[1z1x]]'> | <StructureSection load='1z1x' size='350' side='right' scene='Disintegrin/Cv/1' caption='Disintegrin, [[1z1x]]'> | ||
== Function == | |||
[[Disintegrin|Disintegrins]] are a family of cysteine-rich toxins from viper venoms which inhibit platelet aggregation and cell adhesion. <ref>PMID:15578957</ref> Over 100 disintegrins have been studied. | [[Disintegrin|Disintegrins]] are a family of cysteine-rich toxins from viper venoms which inhibit platelet aggregation and cell adhesion. <ref>PMID:15578957</ref> Over 100 disintegrins have been studied. | ||
== Relevance == | |||
Disintegrins which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>. | Disintegrins which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>. | ||
