Sandbox GGC2: Difference between revisions
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== Structure == | == Structure == | ||
Glucokinase is a protein contains 465 amino acid residues which make up two domains, including a <scene name='75/752269/Small_domain__green/1'>small domain</scene> and a <scene name='75/752269/ | Glucokinase is a protein contains 465 amino acid residues which make up two domains, including a <scene name='75/752269/Small_domain__green/1'>small domain</scene> and a <scene name='75/752269/Small_domain__green/1'>large domain</scene>. | ||
When glucose molecule binds to the <scene name='75/752269/Gkactivesite_glucose/3'>active site</scene> of glucoskinase, it forms hydrogen bonds with <scene name='75/752269/Gkactivesite_glucose/2'>Asn 204, Asp 205, Asn 231, Glu 256 and Glu 290</scene>. At the allosteric site, either glucokinase activators (GKA) or glucokinase inhibitor (GKI)will bind to regulate the activity of glucokinase by changing the confirmation. JSmol structure shows an example of GK-GKA complex, where the GKA bind to the allosteric site. | When glucose molecule binds to the <scene name='75/752269/Gkactivesite_glucose/3'>active site</scene> of glucoskinase, it forms hydrogen bonds with <scene name='75/752269/Gkactivesite_glucose/2'>Asn 204, Asp 205, Asn 231, Glu 256 and Glu 290</scene>. At the allosteric site, either glucokinase activators (GKA) or glucokinase inhibitor (GKI)will bind to regulate the activity of glucokinase by changing the confirmation. JSmol structure shows an example of GK-GKA complex, where the GKA bind to the allosteric site. | ||
== Function == | == Function == | ||
<scene name='75/752269/Intro_2/3'>active site(yellow)and allosteric site (dark blue)</scene> | <scene name='75/752269/Intro_2/3'>active site(yellow)and allosteric site (dark blue)</scene> | ||
<scene name='75/752269/Intro_2/1'>^_^</scene> | <scene name='75/752269/Intro_2/1'>^_^</scene> | ||
