Sandbox GGC2: Difference between revisions

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==Glucokinase==
==Glucokinase==
<StructureSection load='3VEV' size='340' side='right' caption='Caption for this structure' scene='75/752269/Intro/1'>
<StructureSection load='3VEV' size='340' side='right' caption='Caption for this structure' scene='75/752269/Intro/1'>
Glucokinase is also known as human hexokinase IV. It is an enzyme that involves in the regulation of glucose homeostasis. Liver and pancreatic cells use glucokinase converts glucose molecule to glucose 6 phosphate.  
Glucokinase is also known as human hexokinase IV <ref>DOI 10.1074/jbc.M111.274126</ref>. It is an enzyme that involves in the regulation of glucose homeostasis. Liver and pancreatic cells use glucokinase converts glucose molecule to glucose 6 phosphate.  


This is a default text for your page '''Sandbox GGC2'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
This is a default text for your page '''Sandbox GGC2'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.


== Structure ==  
== Structure and Function==  
Glucokinase is a protein contains 465 amino acid residues which make up two domains, including a <scene name='75/752269/Small_domain__green/1'>small domain</scene> and a <scene name='75/752269/Small_domain__green/1'>large domain</scene>.
Glucokinase is a protein contains 465 amino acid residues which make up two domains, including a <scene name='75/752269/Small_domain__green/1'>small domain</scene> and a <scene name='75/752269/Small_domain__green/1'>large domain</scene>.
When glucose molecule binds to the <scene name='75/752269/Gkactivesite_glucose/4'>active site</scene> of glucoskinase, it forms hydrogen bonds with <scene name='75/752269/Gkactivesite_glucose/2'>Asn 204, Asp 205, Asn 231, Glu 256 and Glu 290</scene>. At the <scene name='75/752269/Gkallosteric/1'>allosteric site</scene>, either glucokinase activators (GKA) or glucokinase inhibitor (GKI) will bind to regulate the activity of glucokinase by changing the confirmation. JSmol structure shows an example of GK-GKA complex, where the GKA bind to the allosteric site.
When glucose molecule binds to the <scene name='75/752269/Gkactivesite_glucose/4'>active site</scene> of glucoskinase, it forms hydrogen bonds with <scene name='75/752269/Gkactivesite_glucose/2'>Asn 204, Asp 205, Asn 231, Glu 256 and Glu 290</scene>. At the <scene name='75/752269/Gkallosteric/1'>allosteric site</scene>, either glucokinase activators (GKA) or glucokinase inhibitor (GKI) will bind to regulate the activity of glucokinase by changing the confirmation. JSmol structure shows an example of GK-GKA complex, where the GKA bind to the allosteric site.
== Function ==
<scene name='75/752269/Intro_2/3'>active site(yellow)and allosteric site (dark blue)</scene>
<scene name='75/752269/Intro_2/1'>^_^</scene>
<scene name='75/752269/Intro/1'>cartoon - Glucokinase without ligand</scene>
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.


</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>
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