5ujc: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of a C.elegans B12-trafficking protein CblC, a human MMACHC homologue== | |||
<StructureSection load='5ujc' size='340' side='right' caption='[[5ujc]], [[Resolution|resolution]] 1.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ujc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UJC FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COB:CO-METHYLCOBALAMIN'>COB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ujc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ujc OCA], [http://pdbe.org/5ujc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ujc RCSB], [http://www.ebi.ac.uk/pdbsum/5ujc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ujc ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MMAC_CAEEL MMAC_CAEEL]] Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives.[UniProtKB:Q9Y4U1] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Banerjee, R]] | |||
[[Category: Brunold, T C]] | |||
[[Category: Koutmos, M]] | |||
[[Category: Krautler, B]] | |||
[[Category: Lesniak, N A]] | |||
[[Category: Li, Z]] | |||
[[Category: Ruetz, M]] | |||
[[Category: Shanmuganathan, A]] | |||
[[Category: Yamada, K]] | |||
[[Category: B12 binding]] | |||
[[Category: B12 processing]] | |||
[[Category: B12 trafficking]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Vitamin b12]] | |||
Revision as of 13:11, 4 May 2017
Crystal structure of a C.elegans B12-trafficking protein CblC, a human MMACHC homologue
| ||||||||||||
