5wrs: Difference between revisions
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==Crystal Structure of Fam20A in complex with ATP== | |||
<StructureSection load='5wrs' size='340' side='right' caption='[[5wrs]], [[Resolution|resolution]] 2.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5wrs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WRS FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wrr|5wrr]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wrs OCA], [http://pdbe.org/5wrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wrs RCSB], [http://www.ebi.ac.uk/pdbsum/5wrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wrs ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN]] Amelogenesis imperfecta - nephrocalcinosis;Amelogenesis imperfecta and gingival hyperplasia syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN]] Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.<ref>PMID:25789606</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Zhu, Q]] | [[Category: Zhu, Q]] | ||
[[Category: Secretory pathway pseudokinase]] | |||
[[Category: Transferase]] | |||
Revision as of 13:13, 4 May 2017
Crystal Structure of Fam20A in complex with ATP
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