Ets1: Difference between revisions

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<StructureSection load='1mdm' size='340' side='right' caption='Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (magenta) and MB-1 promoter DNA (PDB code [[1mdm]]).' scene='59/595751/Cv/1'
<StructureSection load='1mdm' size='340' side='right' caption='Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (magenta) and MB-1 promoter DNA (PDB code [[1mdm]]).' scene='59/595751/Cv/1'>
 
== Function ==
== Function ==
'''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor.  Ets1 contributes to the regulation of cellular differentiation<ref>PMID:17986575</ref>  .   
'''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor.  Ets1 contributes to the regulation of cellular differentiation<ref>PMID:17986575</ref>  .   
== Relevance ==
== Relevance ==
Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells.
Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells.
== Structural highlights ==
== Structural highlights ==
Ets1 contains an ETS domain (residues 332-415) which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T.  The ETS domain is flanked by autoinhibitory domains.  At the N-terminal, Ets1 contains a pointed domain (PNT) (residues 54-135) and a MAP kinase phosphorylation domain.  PNT domain is related to SAM domains and contains 4 α-helices.
Ets1 contains an ETS domain (residues 332-415) which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T.  The ETS domain is flanked by autoinhibitory domains.  At the N-terminal, Ets1 contains a pointed domain (PNT) (residues 54-135) and a MAP kinase phosphorylation domain.  PNT domain is related to SAM domains and contains 4 α-helices.


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