Exotoxin: Difference between revisions
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<StructureSection load='3q9o' size='400' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'> | <StructureSection load='3q9o' size='400' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'> | ||
== Function == | |||
Exotoxins (ET) are toxins which are secreted by bacteria<ref>PMID:17675409</ref>. <scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres. | Exotoxins (ET) are toxins which are secreted by Gram-positive and Gram-negative bacteria<ref>PMID:17675409</ref>. ETs are heat labile. They are highly toxic and fatal in μg quantities. ETs bind to specific receptors and have no enzymatic activity. | ||
== Relevance == | |||
Exotoxins are involved in tetanus, diphtheria and botulism. | |||
== Structural highlights == | |||
<scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres. | |||
</StructureSection> | </StructureSection> | ||
