5n2v: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5n2v is ~~ON HOLD until Paper Publication~~

==Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme==

~~Authors~~: ~~Holdermann~~, I., ~~Sprangers~~, R.

== Structural highlights ==

<table><tr><td colspan='2'>[[5n2v]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N2V FirstGlance]. <br>

~~Description~~: ~~Crystal~~ structure of ~~protein~~-~~RNA complex~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8NK:7-METHYLGUANOSINE+5-DIPHOSPHATE'>8NK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2v OCA], [http://pdbe.org/5n2v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2v RCSB], [http://www.ebi.ac.uk/pdbsum/5n2v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2v ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DCP1_SCHPO DCP1_SCHPO]] Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:15671491</ref> [[http://www.uniprot.org/uniprot/DCP2_SCHPO DCP2_SCHPO]] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:15671491</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Holdermann, I]]

[[Category: Sprangers, R]]

[[Category: ~~Holdermann, I~~]]

[[Category: Rna binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5n2v is ON HOLD  until Paper Publication
+==Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme==
+<StructureSection load='5n2v' size='340' side='right' caption='[[5n2v]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-Authors: Holdermann, I., Sprangers, R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5n2v]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N2V FirstGlance]. <br>
-Description: Crystal structure of protein-RNA complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8NK:7-METHYLGUANOSINE+5-DIPHOSPHATE'>8NK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2v OCA], [http://pdbe.org/5n2v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2v RCSB], [http://www.ebi.ac.uk/pdbsum/5n2v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2v ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DCP1_SCHPO DCP1_SCHPO]] Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:15671491</ref>  [[http://www.uniprot.org/uniprot/DCP2_SCHPO DCP2_SCHPO]] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:15671491</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Holdermann, I]]
 [[Category: Sprangers, R]]
-[[Category: Holdermann, I]]
+[[Category: Rna binding protein]]